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dc.creatorStanković, Miroslava
dc.creatorHorvat, Anica
dc.date.accessioned2018-03-01T20:30:40Z
dc.date.available2018-03-01T20:30:40Z
dc.date.issued2008
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/3505
dc.description.abstractThis study addresses the in vitro protective effects of proanthocyanidins and quercetin on the frequency of micronuclei with reference to the antioxidant status of cultured human lymphocytes also subjected to 2 Gy of gamma-radiation. Treatment of lymphocytes with proanthocyanidins induced a significant decrease in the frequency of micronuclei and reduction of malonyldialdehyde production, as well as increased catalase and glutathione S-transferase activity Quercetin induces a higher incidence of micronuclei and production of malonyldialdehyde. The seven-fold increase of micronuclei frequency induced by a therapeutic dose of gamma-radiation was decreased in the presence of proanthocyanidins. These results demonstrate that proanthocyanidins may be important in the prevention of ROS-induced oxidative lymphocyte damage by decreasing DNA damage, lowering membrane lipid peroxidation, and increasing the activity AOP enzymes, as well as by reducing the level of gamma-radiation-induced DNA damage. Our results support the potential benefits of proanthocyanidins as efficient antioxidants and radioprotectors.en
dc.relationSerbian Ministry of Science [143044B]
dc.rightsopenAccessen
dc.sourceArchives of biological sciencesen
dc.subjectmicronucleus testen
dc.subjectflavonoidsen
dc.subjectmalonyldialdehydeen
dc.subjectcatalaseen
dc.subjectglutathione S-transferaseen
dc.subjectgamma-radiationen
dc.subjecthuman lymphocytesen
dc.titleProperties of grape seed Proanthocyanidins and quercetin in human lymphocytesen
dc.typearticleen
dcterms.abstractХорват, Aница; Станковиц, Мирослава;
dc.citation.volume60
dc.citation.issue3
dc.citation.spage367
dc.citation.epage377
dc.identifier.wos000258524700005
dc.identifier.doi10.2298/ABS0803367S
dc.identifier.scopus2-s2.0-53549096234
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/12475/3501.pdf


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