Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease

2007
Authors
Stanković, Aleksandra
Stanković, Sanja
Jovanovic-Markovic, Zagorka
Živković, Maja

Đurić, Tamara

Glišić, Sanja

Alavantić, Dragan

Article
Metadata
Show full item recordAbstract
The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.
Keywords:
ApoB / ischemic cerebrovascular disease / gene / polymorphism / human population / SerbiaSource:
Archives of Biological Sciences, 2007, 59, 4, 303-309Funding / projects:
Institution/Community
VinčaTY - JOUR AU - Stanković, Aleksandra AU - Stanković, Sanja AU - Jovanovic-Markovic, Zagorka AU - Živković, Maja AU - Đurić, Tamara AU - Glišić, Sanja AU - Alavantić, Dragan PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3419 AB - The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk. T2 - Archives of Biological Sciences T1 - Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease VL - 59 IS - 4 SP - 303 EP - 309 DO - 10.2298/ABS0704303S ER -
@article{ author = "Stanković, Aleksandra and Stanković, Sanja and Jovanovic-Markovic, Zagorka and Živković, Maja and Đurić, Tamara and Glišić, Sanja and Alavantić, Dragan", year = "2007", abstract = "The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.", journal = "Archives of Biological Sciences", title = "Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease", volume = "59", number = "4", pages = "303-309", doi = "10.2298/ABS0704303S" }
Stanković, A., Stanković, S., Jovanovic-Markovic, Z., Živković, M., Đurić, T., Glišić, S.,& Alavantić, D.. (2007). Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease. in Archives of Biological Sciences, 59(4), 303-309. https://doi.org/10.2298/ABS0704303S
Stanković A, Stanković S, Jovanovic-Markovic Z, Živković M, Đurić T, Glišić S, Alavantić D. Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease. in Archives of Biological Sciences. 2007;59(4):303-309. doi:10.2298/ABS0704303S .
Stanković, Aleksandra, Stanković, Sanja, Jovanovic-Markovic, Zagorka, Živković, Maja, Đurić, Tamara, Glišić, Sanja, Alavantić, Dragan, "Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease" in Archives of Biological Sciences, 59, no. 4 (2007):303-309, https://doi.org/10.2298/ABS0704303S . .