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dc.creatorMarković, Zoran M.
dc.creatorTodorović-Marković, Biljana
dc.creatorKleut, Duška
dc.creatorNikolić, Nadežda S.
dc.creatorVranješ-Đurić, Sanja
dc.creatorMisirkić, Maja
dc.creatorVucicevic, Ljubica
dc.creatorJanjetović, Kristina D.
dc.creatorIsaković, Aleksandra J.
dc.creatorHarhaji, Ljubica M.
dc.creatorBabić-Stojić Branka S.
dc.creatorDramićanin, Miroslav
dc.creatorTrajković, Vladimir S.
dc.date.accessioned2018-03-01T20:15:01Z
dc.date.available2018-03-01T20:15:01Z
dc.date.issued2007
dc.identifier.issn0142-9612 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/3322
dc.description.abstractBecause of the ability to induce cell death in certain conditions, the fullerenes (C-60) are potential anticancer and toxic agents. The colloidal suspension of crystalline C-60 (nano-C-60, nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental analysis and mathematical modelling, we investigate the requirements for the reactive oxygen species (ROS)-mediated cytotoxicity of different nC(60) suspensions, prepared by solvent exchange method in tetrahydrofuran (THF/nC(60)) and ethanol (EtOH/nC(60)), or by extended mixing in water (aqu/nC(60)). With regard to their capacity to generate ROS and cause mitochondrial depolarization followed by necrotic cell death, the nC(60) suspensions are ranked in the following order: THF/nC(60) GT EtOH/nC(60) GT aqu/nC(60). Mathematical modelling of singlet oxygen (O-1(2)) generation indicates that the O-1(2)-quenching power (THF/nC(60) LT EtOH/nC(60) LT aqU/nC(60)) of the solvent intercalated in the fullerene crystals determines their ability to produce ROS and cause cell damage. These data could. have important implications for toxicology and biomedical application of colloidal fullerenes. (C) 2007 Elsevier Ltd. All rights reserved.en
dc.rightsrestrictedAccessen
dc.sourceBiomaterialsen
dc.subjectcarbonen
dc.subjectnanoparticleen
dc.subjectcytotoxicityen
dc.subjectfree radicalen
dc.subjectmodellingen
dc.titleThe mechanism of cell-damaging reactive oxygen generation by colloidal fullerenesen
dc.typearticleen
dcterms.abstractНиколиц, Надезда; Мисиркиц, Маја; Исаковиц, Aлександра; Хархаји, Љубица; Марковић Зоран; Тодоровић-Марковић Биљана; Клеут Душка; Врањеш-Дјурић Сања; Вуцицевиц, Љубица; Јањетовиц, Кристина; Бабић-Стојић Бранка С.; Драмићанин Мирослав; Трајковиц, Владимир;
dc.citation.volume28
dc.citation.issue36
dc.citation.spage5437
dc.citation.epage5448
dc.identifier.wos000251359000005
dc.identifier.doi10.1016/j.biomaterials.2007.09.002
dc.citation.rankM21a
dc.identifier.pmid17884160
dc.identifier.scopus2-s2.0-35348935601


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