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dc.creatorĐurić, Tamara
dc.creatorŽivković, Maja
dc.creatorStanković, Aleksandra
dc.creatorDinčić, Evica
dc.creatorRaičević, Ranko
dc.creatorAlavantić, Dragan
dc.date.accessioned2018-03-01T20:07:47Z
dc.date.available2018-03-01T20:07:47Z
dc.date.issued2008
dc.identifier.issn0022-510X
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/3237
dc.description.abstractMatrix metalloproteinases (MMPs) are proteolytic enzymes involved in remodeling of the extracellular matrix. MMPs are suggested to play a role in the influx of inflammatory cells into the CNS, disruption of the blood brain barrier, and to degrade myelin in vitro. In this study, we have investigated the possible association of MMP-3 5A/6A gene polymorphism with MS susceptibility and/or severity in patients from Serbia. A total of 184 MS patients (150 RR, 34 SP) and 236 controls have been studied. Results show that the distribution of MMP-3 5A/6A genotype frequencies between NIS patients and controls were not significantly different. In bout onset patients, carriers of MMP-3 6A/6A genotype had significantly higher mean MSSS values compared to the carriers of 5A allele (6.29 +/- 1.89 vs. 5.29 +/- 2.62, respectively, ANCOVA, p=0.01 Scheffe post-hoc test). In conclusion, our results indicate association of MMP-3 6A/6A genotype with significantly higher mean MSSS values. Thus, the obtained results suggest that it should be carefully considered during follow up of patients with MS. Further genetic and functional studies are needed to resolve the complex role of MMPs and their tissue inhibitors in NIS pathology and/or regeneration. (C) 2007 Elsevier B.V. All rights reserved.en
dc.rightsrestrictedAccessen
dc.sourceJournal of the Neurological Sciencesen
dc.subjectMMP-3en
dc.subjectgene polymorphismen
dc.subjectmultiple sclerosisen
dc.subjectMSSSen
dc.titleAssociation of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbiaen
dc.typearticleen
dcterms.abstractДинциц, Евица; Раиевиц, Рарлко; Ђурић Тамара; Живковић Маја; Станковић Aлександра; Aлавантић Драган;
dc.citation.volume267
dc.citation.issue1-2
dc.citation.spage62
dc.citation.epage65
dc.identifier.wos000254180600010
dc.identifier.doi10.1016/j.jns.2007.09.037
dc.citation.rankM22
dc.identifier.pmid17942123
dc.identifier.scopus2-s2.0-39149105944


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