Skewed X-Chromosome Inactivation in Women Affected by Alzheimers Disease
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Bajić, Vladan P.Mandušić, Vesna
Stefanova, Elka
Božović, Ana M.
Davidović, Radoslav S.
Živković, Lada
Čabarkapa, Andrea
Spremo-Potparević, Biljana
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X-chromosome instability has been a long established feature in Alzheimers disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD? To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns ( GT 90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.
Keywords:
Alzheimers disease / aneuploidy / methylation specific qPCR / X-chromosome / X-chromosome skewingSource:
Journal of Alzheimers Disease, 2015, 43, 4, 1251-1259Funding / projects:
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-MESTD-Basic Research (BR or ON)-173034)
- Molecular determinants for tumor marker design (RS-MESTD-Basic Research (BR or ON)-173049)
DOI: 10.3233/JAD-141674
ISSN: 1387-2877; 1875-8908
PubMed: 25159673
WoS: 000346857400014
Scopus: 2-s2.0-84919880287
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VinčaTY - JOUR AU - Bajić, Vladan P. AU - Mandušić, Vesna AU - Stefanova, Elka AU - Božović, Ana M. AU - Davidović, Radoslav S. AU - Živković, Lada AU - Čabarkapa, Andrea AU - Spremo-Potparević, Biljana PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/314 AB - X-chromosome instability has been a long established feature in Alzheimers disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD? To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns ( GT 90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women. T2 - Journal of Alzheimers Disease T1 - Skewed X-Chromosome Inactivation in Women Affected by Alzheimers Disease VL - 43 IS - 4 SP - 1251 EP - 1259 DO - 10.3233/JAD-141674 ER -
@article{ author = "Bajić, Vladan P. and Mandušić, Vesna and Stefanova, Elka and Božović, Ana M. and Davidović, Radoslav S. and Živković, Lada and Čabarkapa, Andrea and Spremo-Potparević, Biljana", year = "2015", abstract = "X-chromosome instability has been a long established feature in Alzheimers disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD? To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns ( GT 90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.", journal = "Journal of Alzheimers Disease", title = "Skewed X-Chromosome Inactivation in Women Affected by Alzheimers Disease", volume = "43", number = "4", pages = "1251-1259", doi = "10.3233/JAD-141674" }
Bajić, V. P., Mandušić, V., Stefanova, E., Božović, A. M., Davidović, R. S., Živković, L., Čabarkapa, A.,& Spremo-Potparević, B.. (2015). Skewed X-Chromosome Inactivation in Women Affected by Alzheimers Disease. in Journal of Alzheimers Disease, 43(4), 1251-1259. https://doi.org/10.3233/JAD-141674
Bajić VP, Mandušić V, Stefanova E, Božović AM, Davidović RS, Živković L, Čabarkapa A, Spremo-Potparević B. Skewed X-Chromosome Inactivation in Women Affected by Alzheimers Disease. in Journal of Alzheimers Disease. 2015;43(4):1251-1259. doi:10.3233/JAD-141674 .
Bajić, Vladan P., Mandušić, Vesna, Stefanova, Elka, Božović, Ana M., Davidović, Radoslav S., Živković, Lada, Čabarkapa, Andrea, Spremo-Potparević, Biljana, "Skewed X-Chromosome Inactivation in Women Affected by Alzheimers Disease" in Journal of Alzheimers Disease, 43, no. 4 (2015):1251-1259, https://doi.org/10.3233/JAD-141674 . .