Skewed X-Chromosome Inactivation in Women Affected by Alzheimers Disease
No Thumbnail
Authors
Bajić, Vladan P.
Mandušić, Vesna

Stefanova, Elka
Božović, Ana M.

Davidović, Radoslav S.

Živković, Lada
Cabarkapa, Andrea
Spremo-Potparević, Biljana

Article
Metadata
Show full item recordAbstract
X-chromosome instability has been a long established feature in Alzheimers disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD? To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns ( GT 90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.
Keywords:
Alzheimers disease / aneuploidy / methylation specific qPCR / X-chromosome / X-chromosome skewingSource:
Journal of Alzheimers Disease, 2015, 43, 4, 1251-1259Projects:
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-173034)
- Molecular determinants for tumor marker design (RS-173049)
DOI: 10.3233/JAD-141674
ISSN: 1387-2877 (print); 1875-8908 (electronic)
PubMed: 25159673