Biocompatibility of nanostructured carbonated calcium hydroxyapatite obtained by hydrothermal method
Апстракт
Evaluation of biomaterials as safe and effective therapies needs preclinical models to estimate their biologic potential. This paper investigates biocompatibility by the in vivo assessment of the muscle tissue reaction after implantation of the hidrothermally produced calciumhydroxyapatite. Specific attention has to be given to the synthesis technique which influences the stereology of the material and the behaviour of the material in living tissues. The synthesized powders of hydroxyapatite are preferentially carbonated hydroxyapatite of the 8 type in the form of agglomerates that accommodate two-modal size pores of 1.5-10 nm and 50-200 nm. The particles are built from crystallites of 8-22 nm in size, bind inside of the prime particles sized is between 10 and 63 nm. They form agglomerates of 200 nm in size and these were further clustered building up the biggest agglomerates of 520 mu m. Biocompatibility assessment revealed that only mild to moderate inflammatory reaction was seen aro...und the calciumhydroxyapatite implants. Calciumhydroxyapatite failed to show any substantional toxicity.
Кључне речи:
biocompatibility / carbonated nano-structured hydroxyapatite / hydrothermal synthesis / tissue implantationИзвор:
Acta Veterinaria, Beograd, 2006, 56, 5-6, 541-551
DOI: 10.2298/AVB0606541M
ISSN: 0567-8315
WoS: 000242961900017
Scopus: 2-s2.0-33846438622
Колекције
Институција/група
VinčaTY - JOUR AU - Marković, D. AU - Zivojinovic, Vesna AU - Jokanović, Vukoman R. AU - Krstic, V PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3131 AB - Evaluation of biomaterials as safe and effective therapies needs preclinical models to estimate their biologic potential. This paper investigates biocompatibility by the in vivo assessment of the muscle tissue reaction after implantation of the hidrothermally produced calciumhydroxyapatite. Specific attention has to be given to the synthesis technique which influences the stereology of the material and the behaviour of the material in living tissues. The synthesized powders of hydroxyapatite are preferentially carbonated hydroxyapatite of the 8 type in the form of agglomerates that accommodate two-modal size pores of 1.5-10 nm and 50-200 nm. The particles are built from crystallites of 8-22 nm in size, bind inside of the prime particles sized is between 10 and 63 nm. They form agglomerates of 200 nm in size and these were further clustered building up the biggest agglomerates of 520 mu m. Biocompatibility assessment revealed that only mild to moderate inflammatory reaction was seen around the calciumhydroxyapatite implants. Calciumhydroxyapatite failed to show any substantional toxicity. T2 - Acta Veterinaria, Beograd T1 - Biocompatibility of nanostructured carbonated calcium hydroxyapatite obtained by hydrothermal method VL - 56 IS - 5-6 SP - 541 EP - 551 DO - 10.2298/AVB0606541M ER -
@article{ author = "Marković, D. and Zivojinovic, Vesna and Jokanović, Vukoman R. and Krstic, V", year = "2006", abstract = "Evaluation of biomaterials as safe and effective therapies needs preclinical models to estimate their biologic potential. This paper investigates biocompatibility by the in vivo assessment of the muscle tissue reaction after implantation of the hidrothermally produced calciumhydroxyapatite. Specific attention has to be given to the synthesis technique which influences the stereology of the material and the behaviour of the material in living tissues. The synthesized powders of hydroxyapatite are preferentially carbonated hydroxyapatite of the 8 type in the form of agglomerates that accommodate two-modal size pores of 1.5-10 nm and 50-200 nm. The particles are built from crystallites of 8-22 nm in size, bind inside of the prime particles sized is between 10 and 63 nm. They form agglomerates of 200 nm in size and these were further clustered building up the biggest agglomerates of 520 mu m. Biocompatibility assessment revealed that only mild to moderate inflammatory reaction was seen around the calciumhydroxyapatite implants. Calciumhydroxyapatite failed to show any substantional toxicity.", journal = "Acta Veterinaria, Beograd", title = "Biocompatibility of nanostructured carbonated calcium hydroxyapatite obtained by hydrothermal method", volume = "56", number = "5-6", pages = "541-551", doi = "10.2298/AVB0606541M" }
Marković, D., Zivojinovic, V., Jokanović, V. R.,& Krstic, V.. (2006). Biocompatibility of nanostructured carbonated calcium hydroxyapatite obtained by hydrothermal method. in Acta Veterinaria, Beograd, 56(5-6), 541-551. https://doi.org/10.2298/AVB0606541M
Marković D, Zivojinovic V, Jokanović VR, Krstic V. Biocompatibility of nanostructured carbonated calcium hydroxyapatite obtained by hydrothermal method. in Acta Veterinaria, Beograd. 2006;56(5-6):541-551. doi:10.2298/AVB0606541M .
Marković, D., Zivojinovic, Vesna, Jokanović, Vukoman R., Krstic, V, "Biocompatibility of nanostructured carbonated calcium hydroxyapatite obtained by hydrothermal method" in Acta Veterinaria, Beograd, 56, no. 5-6 (2006):541-551, https://doi.org/10.2298/AVB0606541M . .