Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex
Нема приказа
Аутори
Miodragović Đenana U.Bogdanović, Goran A.
Miodragovic, Zoran M.
Radulovic, Milanka D.
Novaković, Slađana B.
Kaluđerović, Goran N.
Kozlowski, Henryk
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Crystal structure of a novel cobalt(III) complex with antiulcer drug famotidine and ethylenediamine was determined. This is the second structure of a transition metal complex with famotidine resolved by a single crystal X-ray analysis, in which famotidine shows different mode of coordination than that observed in the other cases. Drug molecule is coordinated to metal ion as a tetradentate ligand through guanidine N6, thiazole N4, thioether S2 and terminal N3 atom. Two NH2 groups (N3H(2) and N6H(2)) are deprotonated and drug coordinates as dianion. In the asymmetric unit, one chloride anion and one water molecule were found to complete the complex stoichiometry. The structure of the complex is abundant in atoms, which can be involved in hydrogen bond formation either as hydrogen acceptors or hydrogen donors. Because of that, a great number of hydrogen bonds dominates the crystal packing. Beside the hydrogen bonds, there are two interesting noncovalent interactions: CH...pi and NH...pi w...ithin the famotidine anion, which stabilize the complex structure. The pi...pi stacking interactions between neighboring complex cations are also observed. Antibacterial and antifungal activity of famotidine and its newly synthesized complex against representative bacteria: Escherichia coli, Staphilococcus aureus and Micrococcus lysodeikticus and fungi: Aspergillus niger and Candida albicans were examined. The results indicate a higher selectivity of the famotidine-Co(III) complex, as well as better growth inhibitory activity (lower MIC values (MIC, minimal inhibitory concentration)) in comparison with the drug alone. (c) 2006 Elsevier Inc. All rights reserved.
Кључне речи:
crystal structure / cobalt(III) complex / famotidine / histamine H2 receptor antagonist / pi interactions / microbiologicalИзвор:
Journal of Inorganic Biochemistry, 2006, 100, 9, 1568-1574
DOI: 10.1016/j.jinorgbio.2006.05.009
ISSN: 0162-0134
PubMed: 16831463
WoS: 000240789000016
Scopus: 2-s2.0-33746874466
Колекције
Институција/група
VinčaTY - JOUR AU - Miodragović Đenana U. AU - Bogdanović, Goran A. AU - Miodragovic, Zoran M. AU - Radulovic, Milanka D. AU - Novaković, Slađana B. AU - Kaluđerović, Goran N. AU - Kozlowski, Henryk PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3091 AB - Crystal structure of a novel cobalt(III) complex with antiulcer drug famotidine and ethylenediamine was determined. This is the second structure of a transition metal complex with famotidine resolved by a single crystal X-ray analysis, in which famotidine shows different mode of coordination than that observed in the other cases. Drug molecule is coordinated to metal ion as a tetradentate ligand through guanidine N6, thiazole N4, thioether S2 and terminal N3 atom. Two NH2 groups (N3H(2) and N6H(2)) are deprotonated and drug coordinates as dianion. In the asymmetric unit, one chloride anion and one water molecule were found to complete the complex stoichiometry. The structure of the complex is abundant in atoms, which can be involved in hydrogen bond formation either as hydrogen acceptors or hydrogen donors. Because of that, a great number of hydrogen bonds dominates the crystal packing. Beside the hydrogen bonds, there are two interesting noncovalent interactions: CH...pi and NH...pi within the famotidine anion, which stabilize the complex structure. The pi...pi stacking interactions between neighboring complex cations are also observed. Antibacterial and antifungal activity of famotidine and its newly synthesized complex against representative bacteria: Escherichia coli, Staphilococcus aureus and Micrococcus lysodeikticus and fungi: Aspergillus niger and Candida albicans were examined. The results indicate a higher selectivity of the famotidine-Co(III) complex, as well as better growth inhibitory activity (lower MIC values (MIC, minimal inhibitory concentration)) in comparison with the drug alone. (c) 2006 Elsevier Inc. All rights reserved. T2 - Journal of Inorganic Biochemistry T1 - Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex VL - 100 IS - 9 SP - 1568 EP - 1574 DO - 10.1016/j.jinorgbio.2006.05.009 ER -
@article{ author = "Miodragović Đenana U. and Bogdanović, Goran A. and Miodragovic, Zoran M. and Radulovic, Milanka D. and Novaković, Slađana B. and Kaluđerović, Goran N. and Kozlowski, Henryk", year = "2006", abstract = "Crystal structure of a novel cobalt(III) complex with antiulcer drug famotidine and ethylenediamine was determined. This is the second structure of a transition metal complex with famotidine resolved by a single crystal X-ray analysis, in which famotidine shows different mode of coordination than that observed in the other cases. Drug molecule is coordinated to metal ion as a tetradentate ligand through guanidine N6, thiazole N4, thioether S2 and terminal N3 atom. Two NH2 groups (N3H(2) and N6H(2)) are deprotonated and drug coordinates as dianion. In the asymmetric unit, one chloride anion and one water molecule were found to complete the complex stoichiometry. The structure of the complex is abundant in atoms, which can be involved in hydrogen bond formation either as hydrogen acceptors or hydrogen donors. Because of that, a great number of hydrogen bonds dominates the crystal packing. Beside the hydrogen bonds, there are two interesting noncovalent interactions: CH...pi and NH...pi within the famotidine anion, which stabilize the complex structure. The pi...pi stacking interactions between neighboring complex cations are also observed. Antibacterial and antifungal activity of famotidine and its newly synthesized complex against representative bacteria: Escherichia coli, Staphilococcus aureus and Micrococcus lysodeikticus and fungi: Aspergillus niger and Candida albicans were examined. The results indicate a higher selectivity of the famotidine-Co(III) complex, as well as better growth inhibitory activity (lower MIC values (MIC, minimal inhibitory concentration)) in comparison with the drug alone. (c) 2006 Elsevier Inc. All rights reserved.", journal = "Journal of Inorganic Biochemistry", title = "Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex", volume = "100", number = "9", pages = "1568-1574", doi = "10.1016/j.jinorgbio.2006.05.009" }
Miodragović Đenana U., Bogdanović, G. A., Miodragovic, Z. M., Radulovic, M. D., Novaković, S. B., Kaluđerović, G. N.,& Kozlowski, H.. (2006). Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex. in Journal of Inorganic Biochemistry, 100(9), 1568-1574. https://doi.org/10.1016/j.jinorgbio.2006.05.009
Miodragović Đenana U., Bogdanović GA, Miodragovic ZM, Radulovic MD, Novaković SB, Kaluđerović GN, Kozlowski H. Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex. in Journal of Inorganic Biochemistry. 2006;100(9):1568-1574. doi:10.1016/j.jinorgbio.2006.05.009 .
Miodragović Đenana U., Bogdanović, Goran A., Miodragovic, Zoran M., Radulovic, Milanka D., Novaković, Slađana B., Kaluđerović, Goran N., Kozlowski, Henryk, "Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex" in Journal of Inorganic Biochemistry, 100, no. 9 (2006):1568-1574, https://doi.org/10.1016/j.jinorgbio.2006.05.009 . .