Association of polymorphisms in CTLA-4, IL-1ra and IL-1 beta genes with multiple sclerosis in Serbian population
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Dinčić, EvicaŽivković, Maja
Stanković, Aleksandra
Obradović, Dragana
Alavantić, Dragan
Kostic, Vladimir
Raičević, Ranko
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We have investigated separate as well as combined influence of IL-1 beta TaqI, IL-1ra VNTR and CTLA-4 +49 A/G polymorphisms on susceptibility, clinical course and progression of MS in 162 Serbian patients. We found significant independent relative risk for MS susceptibility in noncarriers of IL-Ira allele 2 (OR=2.2, CI= 1.3-3.7, p=0.003) and CTLA-4 +49 AA genotype (OR=2.0, CI=1.2-3.5, p=0.01) as well as their combined effect (OR=4.4, CI=2.0-9.7, p=0.0003). Our result supports the significant and combined effect of IL-1ra VNTR and CTLA-4 polymorphisms on MS justifying the need for further haplotype analysis in different populations. (c) 2006 Elsevier B.V. All rights reserved.
Keywords:
IL-1 beta / IL-1ra / CTLA-4 / gene / polymorphisms / multiple sclerosisSource:
Journal of Neuroimmunology, 2006, 177, 1-2, 146-150
DOI: 10.1016/j.jneuroim.2006.05.005
ISSN: 0165-5728
PubMed: 16769128
WoS: 000240261100016
Scopus: 2-s2.0-33746295346
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VinčaTY - JOUR AU - Dinčić, Evica AU - Živković, Maja AU - Stanković, Aleksandra AU - Obradović, Dragana AU - Alavantić, Dragan AU - Kostic, Vladimir AU - Raičević, Ranko PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3078 AB - We have investigated separate as well as combined influence of IL-1 beta TaqI, IL-1ra VNTR and CTLA-4 +49 A/G polymorphisms on susceptibility, clinical course and progression of MS in 162 Serbian patients. We found significant independent relative risk for MS susceptibility in noncarriers of IL-Ira allele 2 (OR=2.2, CI= 1.3-3.7, p=0.003) and CTLA-4 +49 AA genotype (OR=2.0, CI=1.2-3.5, p=0.01) as well as their combined effect (OR=4.4, CI=2.0-9.7, p=0.0003). Our result supports the significant and combined effect of IL-1ra VNTR and CTLA-4 polymorphisms on MS justifying the need for further haplotype analysis in different populations. (c) 2006 Elsevier B.V. All rights reserved. T2 - Journal of Neuroimmunology T1 - Association of polymorphisms in CTLA-4, IL-1ra and IL-1 beta genes with multiple sclerosis in Serbian population VL - 177 IS - 1-2 SP - 146 EP - 150 DO - 10.1016/j.jneuroim.2006.05.005 ER -
@article{ author = "Dinčić, Evica and Živković, Maja and Stanković, Aleksandra and Obradović, Dragana and Alavantić, Dragan and Kostic, Vladimir and Raičević, Ranko", year = "2006", abstract = "We have investigated separate as well as combined influence of IL-1 beta TaqI, IL-1ra VNTR and CTLA-4 +49 A/G polymorphisms on susceptibility, clinical course and progression of MS in 162 Serbian patients. We found significant independent relative risk for MS susceptibility in noncarriers of IL-Ira allele 2 (OR=2.2, CI= 1.3-3.7, p=0.003) and CTLA-4 +49 AA genotype (OR=2.0, CI=1.2-3.5, p=0.01) as well as their combined effect (OR=4.4, CI=2.0-9.7, p=0.0003). Our result supports the significant and combined effect of IL-1ra VNTR and CTLA-4 polymorphisms on MS justifying the need for further haplotype analysis in different populations. (c) 2006 Elsevier B.V. All rights reserved.", journal = "Journal of Neuroimmunology", title = "Association of polymorphisms in CTLA-4, IL-1ra and IL-1 beta genes with multiple sclerosis in Serbian population", volume = "177", number = "1-2", pages = "146-150", doi = "10.1016/j.jneuroim.2006.05.005" }
Dinčić, E., Živković, M., Stanković, A., Obradović, D., Alavantić, D., Kostic, V.,& Raičević, R.. (2006). Association of polymorphisms in CTLA-4, IL-1ra and IL-1 beta genes with multiple sclerosis in Serbian population. in Journal of Neuroimmunology, 177(1-2), 146-150. https://doi.org/10.1016/j.jneuroim.2006.05.005
Dinčić E, Živković M, Stanković A, Obradović D, Alavantić D, Kostic V, Raičević R. Association of polymorphisms in CTLA-4, IL-1ra and IL-1 beta genes with multiple sclerosis in Serbian population. in Journal of Neuroimmunology. 2006;177(1-2):146-150. doi:10.1016/j.jneuroim.2006.05.005 .
Dinčić, Evica, Živković, Maja, Stanković, Aleksandra, Obradović, Dragana, Alavantić, Dragan, Kostic, Vladimir, Raičević, Ranko, "Association of polymorphisms in CTLA-4, IL-1ra and IL-1 beta genes with multiple sclerosis in Serbian population" in Journal of Neuroimmunology, 177, no. 1-2 (2006):146-150, https://doi.org/10.1016/j.jneuroim.2006.05.005 . .