The Informational Spectrum Method (ISM) is the tool for the in silico analysis of proteins which interprets protein sequence linear information using signal analyses methods. In this paper the ISM was employed to characterize the products of genetic variants of tumor suppressor gene p53 and its natural binding regulator protein Mdm2. Based on this we propose the criterion for identification of missense mutations that have impact on the p53-Mdm2 feedback loop. The efficiency of the proposed criterion was confirmed by the ISM analyses of p53 mutants reported in: (i) healthy individuals, (ii) germline mutations database and (iii) somatic mutations database.
TY - JOUR
AU - Veljković, Nevena V.
AU - Perović, Vladimir R.
PY - 2006
UR - http://vinar.vin.bg.ac.rs/handle/123456789/3063
AB - The Informational Spectrum Method (ISM) is the tool for the in silico analysis of proteins which interprets protein sequence linear information using signal analyses methods. In this paper the ISM was employed to characterize the products of genetic variants of tumor suppressor gene p53 and its natural binding regulator protein Mdm2. Based on this we propose the criterion for identification of missense mutations that have impact on the p53-Mdm2 feedback loop. The efficiency of the proposed criterion was confirmed by the ISM analyses of p53 mutants reported in: (i) healthy individuals, (ii) germline mutations database and (iii) somatic mutations database.
T2 - Protein and Peptide Letters
T1 - In silico criterion for prediction of effects of p53 gene missense mutations on p53-Mdm2 feedback loop
VL - 13
IS - 8
SP - 807
EP - 814
DO - 10.2174/092986606777841181
ER -
@article{
author = "Veljković, Nevena V. and Perović, Vladimir R.",
year = "2006",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/3063",
abstract = "The Informational Spectrum Method (ISM) is the tool for the in silico analysis of proteins which interprets protein sequence linear information using signal analyses methods. In this paper the ISM was employed to characterize the products of genetic variants of tumor suppressor gene p53 and its natural binding regulator protein Mdm2. Based on this we propose the criterion for identification of missense mutations that have impact on the p53-Mdm2 feedback loop. The efficiency of the proposed criterion was confirmed by the ISM analyses of p53 mutants reported in: (i) healthy individuals, (ii) germline mutations database and (iii) somatic mutations database.",
journal = "Protein and Peptide Letters",
title = "In silico criterion for prediction of effects of p53 gene missense mutations on p53-Mdm2 feedback loop",
volume = "13",
number = "8",
pages = "807-814",
doi = "10.2174/092986606777841181"
}
Veljković NV, Perović VR. In silico criterion for prediction of effects of p53 gene missense mutations on p53-Mdm2 feedback loop. Protein and Peptide Letters. 2006;13(8):807-814
Veljković, N. V.,& Perović, V. R. (2006). In silico criterion for prediction of effects of p53 gene missense mutations on p53-Mdm2 feedback loop.
Protein and Peptide Letters, 13(8), 807-814.
https://doi.org/10.2174/092986606777841181
Veljković Nevena V., Perović Vladimir R., "In silico criterion for prediction of effects of p53 gene missense mutations on p53-Mdm2 feedback loop" 13, no. 8 (2006):807-814,
https://doi.org/10.2174/092986606777841181 .
