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Time-Related Sex Diffrences in Cerebral Hypoperfusion-Induced Brain Injury

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2014
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Authors
Stanojlović, Miloš R.
Guševac, Ivana
Grković, Ivana
Mitrović, Nataša Lj.
Horvat, Anica
Drakulić, Dunja R.
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Abstract
Although the model of cerebral hypoperfusion in rats has been a matter of many investigations over the years, the exact intracellular and biochemical mechanisms that lead to neuron loss and memory decline have not been clearly identified. In the current study, we examined whether cerebral hypoperfusion causes changes in hippocampal protein expression of apoptotic markers in the synaptosomal fraction and neurodegeneration in a time-dependent and sex-specific manner. Adult male and female Wistar rats were divided into two main groups, controls that underwent sham operation, and animals subjected to permanent bilateral occlusion of common carotid arteries. Both male and female rats were killed 3, 7 or 90 days following the insult. The obtained results indicate that the peak of processes that lead to apoptosis occured on postoperative day 7 and that they were more prominent in males, indicating that neuroprotective effects of certain substances (planned for future experiments), should be t...ested at this time point.

Keywords:
cerebral hypoperfusion / apoptosis / gender / hippocampus
Source:
Archives of biological sciences, 2014, 66, 4, 1673-1680
Projects:
  • Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-173044)
  • Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy (RS-41014)

DOI: 10.2298/ABS1404673S

ISSN: 0354-4664; 1821-4339

WoS: 000346477900045

Scopus: 2-s2.0-84921652306
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URI
http://vinar.vin.bg.ac.rs/handle/123456789/301
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