Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia
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Objectives: Lipoprotein(a) (Lp(a)) concentration is determined primarily by the apolipoprotein(a) (apo(a)) gene. The pentanucleotide (TTTTA)n repeat and G/A-914 polymorphisms are in the 5 promoter region of the apo(a) gene. To elucidate whether these polymorphisms affect Lp(a) levels, a total of 211 Serbian adults were investigated. esign: One hundred and eleven patients with ischemic heart disease and 100 healthy controls were genotyped and Lp(a) levels determined. Results: Lp(a) concentrations differed according to the (TTTTA)n genotypes: among those having at least one allele 8, patients had significantly higher Lp(a) values than controls. A decreasing trend of Lp(a) values was associated with the -914A allele in controls but the opposite was true in patients. Patients with genotype TTTTA allele 8/AA-914 had significantly higher Lp(a) values than those without allele 8/AA (p LT 0.05). The GT 8 GT 8/GG genotype was not detected. Significant linkage disequilibrium between (TTTTA)n and... G/A-914 polymorphism (p LT 0.001) was found. In multivariate regression analysis, the G/A-914 polymorphism significantly (p LT 0.05) affected Lp(a) levels in patients, after taking into account the (TTTTA)n polymorphism. Conclusion: These results indicate that (TTTTA)n and G/A-914 polymorphisms affect Lp(a) levels in ischemic heart disease as a consequence of the linkage disequlibnum.