Somatic DNA damage in interventional cardiologists: a case control study
Нема приказа
Аутори
Andreassi, MGCioppa, A
Botto, N
Joksić, Gordana
Manfredi, S
Federici, C
Stojić, M.
Rubino, P
Picano, E
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Interventional cardiologists who work in cardiac catheterization laboratories are exposed to low doses of ionizing radiation that could pose a health hazard. DNA damage is considered to be the main initiating event by which radiation damage to cells results in development of cancer and hereditary disease. The aim of the present study was to assess the effects of chronic low-dose X-ray radiation exposure on somatic DNA damage of interventional cardiologists working in high-volume cardiac catheterization laboratories. For this analysis, we used peripheral lymphocytes and the assay for micronuclei (MNs), which is considered to be a reliable biological dosimeter for radiation exposure. We obtained peripheral blood from 62 physicians (mean age+/-se = 40.6+/-1.5 years): 31 interventional cardiologists (group I, exposed) and 31 age- and sex-matched clinical cardiologists (group II, nonexposed). Interventional cardiologists showed higher MN values (group I=20.5+/-1.6 vs. group II=12.8+/-1.3, P...=0.001), although some overlap was apparent in the individual subject analysis. A correlation between years of professional activity and MN frequency value was detectable for interventional cardiologists (r=0.428, P=0.02) but not for clinical cardiologists (r=0.253, P=0.17). The results indicated that, overall, interventional cardiologists working in a high-volume catheterization laboratory have higher levels of somatic DNA damage when compared with clinical cardiologists working outside the catheterization laboratory. The amount of this damage varies and is only weakly related to the duration of professional exposure, which suggests that a dominant modulation of the underlying genetic substrate by environmental factors has a role in determining the harm in individual physicians.
Кључне речи:
MN assay / professional radiation exposure / low-dose radiation / human lymphocytesИзвор:
FASEB Journal, 2005, 19, 3, 998-+
DOI: 10.1096/fj.04-3287fje
ISSN: 0892-6638
PubMed: 15802491
WoS: 000227901300042
Scopus: 2-s2.0-20444448133
Колекције
Институција/група
VinčaTY - JOUR AU - Andreassi, MG AU - Cioppa, A AU - Botto, N AU - Joksić, Gordana AU - Manfredi, S AU - Federici, C AU - Stojić, M. AU - Rubino, P AU - Picano, E PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2873 AB - Interventional cardiologists who work in cardiac catheterization laboratories are exposed to low doses of ionizing radiation that could pose a health hazard. DNA damage is considered to be the main initiating event by which radiation damage to cells results in development of cancer and hereditary disease. The aim of the present study was to assess the effects of chronic low-dose X-ray radiation exposure on somatic DNA damage of interventional cardiologists working in high-volume cardiac catheterization laboratories. For this analysis, we used peripheral lymphocytes and the assay for micronuclei (MNs), which is considered to be a reliable biological dosimeter for radiation exposure. We obtained peripheral blood from 62 physicians (mean age+/-se = 40.6+/-1.5 years): 31 interventional cardiologists (group I, exposed) and 31 age- and sex-matched clinical cardiologists (group II, nonexposed). Interventional cardiologists showed higher MN values (group I=20.5+/-1.6 vs. group II=12.8+/-1.3, P=0.001), although some overlap was apparent in the individual subject analysis. A correlation between years of professional activity and MN frequency value was detectable for interventional cardiologists (r=0.428, P=0.02) but not for clinical cardiologists (r=0.253, P=0.17). The results indicated that, overall, interventional cardiologists working in a high-volume catheterization laboratory have higher levels of somatic DNA damage when compared with clinical cardiologists working outside the catheterization laboratory. The amount of this damage varies and is only weakly related to the duration of professional exposure, which suggests that a dominant modulation of the underlying genetic substrate by environmental factors has a role in determining the harm in individual physicians. T2 - FASEB Journal T1 - Somatic DNA damage in interventional cardiologists: a case control study VL - 19 IS - 3 SP - 998 EP - + DO - 10.1096/fj.04-3287fje ER -
@article{ author = "Andreassi, MG and Cioppa, A and Botto, N and Joksić, Gordana and Manfredi, S and Federici, C and Stojić, M. and Rubino, P and Picano, E", year = "2005", abstract = "Interventional cardiologists who work in cardiac catheterization laboratories are exposed to low doses of ionizing radiation that could pose a health hazard. DNA damage is considered to be the main initiating event by which radiation damage to cells results in development of cancer and hereditary disease. The aim of the present study was to assess the effects of chronic low-dose X-ray radiation exposure on somatic DNA damage of interventional cardiologists working in high-volume cardiac catheterization laboratories. For this analysis, we used peripheral lymphocytes and the assay for micronuclei (MNs), which is considered to be a reliable biological dosimeter for radiation exposure. We obtained peripheral blood from 62 physicians (mean age+/-se = 40.6+/-1.5 years): 31 interventional cardiologists (group I, exposed) and 31 age- and sex-matched clinical cardiologists (group II, nonexposed). Interventional cardiologists showed higher MN values (group I=20.5+/-1.6 vs. group II=12.8+/-1.3, P=0.001), although some overlap was apparent in the individual subject analysis. A correlation between years of professional activity and MN frequency value was detectable for interventional cardiologists (r=0.428, P=0.02) but not for clinical cardiologists (r=0.253, P=0.17). The results indicated that, overall, interventional cardiologists working in a high-volume catheterization laboratory have higher levels of somatic DNA damage when compared with clinical cardiologists working outside the catheterization laboratory. The amount of this damage varies and is only weakly related to the duration of professional exposure, which suggests that a dominant modulation of the underlying genetic substrate by environmental factors has a role in determining the harm in individual physicians.", journal = "FASEB Journal", title = "Somatic DNA damage in interventional cardiologists: a case control study", volume = "19", number = "3", pages = "998-+", doi = "10.1096/fj.04-3287fje" }
Andreassi, M., Cioppa, A., Botto, N., Joksić, G., Manfredi, S., Federici, C., Stojić, M., Rubino, P.,& Picano, E.. (2005). Somatic DNA damage in interventional cardiologists: a case control study. in FASEB Journal, 19(3), 998-+. https://doi.org/10.1096/fj.04-3287fje
Andreassi M, Cioppa A, Botto N, Joksić G, Manfredi S, Federici C, Stojić M, Rubino P, Picano E. Somatic DNA damage in interventional cardiologists: a case control study. in FASEB Journal. 2005;19(3):998-+. doi:10.1096/fj.04-3287fje .
Andreassi, MG, Cioppa, A, Botto, N, Joksić, Gordana, Manfredi, S, Federici, C, Stojić, M., Rubino, P, Picano, E, "Somatic DNA damage in interventional cardiologists: a case control study" in FASEB Journal, 19, no. 3 (2005):998-+, https://doi.org/10.1096/fj.04-3287fje . .