The pattern and intensity of glucocorticoid receptor (GR) and heat shock 70 protein (Hsp 70) changes in the hippocampus and brain cortex of adult Wistar rat males exposed to acute (immobilization, cold) and chronic (social isolation, crowding, daily swimming) stress or their combinations were followed by Western immunoblotting. Plasma ACTH and CORT were measured by chemiluminescent method and RIA. A significant decrease in cytosol GR and Hsp 70 was observed after acute stress, while chronic stresses led to negligible changes in both these proteins and caused a reduced responsiveness to a novel acute stress. This was valid irrespective of the type of chronic or acute stress combinations for both hippocampal and cortical GR and Hsp 70. The results support the hypothesis that chronic stress-induced deregulation of the LHPA axis may be caused, at least in part, by partial disruption of intracelullar negative feedback control in the higher centers of the brain. Copyright (C) 2005 S. Karger ...AG, Basel.
TY - JOUR
AU - Filipović, Dragana
AU - Gavrilović, Ljubica
AU - Dronjak, Slađana
AU - Radojčić, Marija
PY - 2005
UR - https://vinar.vin.bg.ac.rs/handle/123456789/2871
AB - The pattern and intensity of glucocorticoid receptor (GR) and heat shock 70 protein (Hsp 70) changes in the hippocampus and brain cortex of adult Wistar rat males exposed to acute (immobilization, cold) and chronic (social isolation, crowding, daily swimming) stress or their combinations were followed by Western immunoblotting. Plasma ACTH and CORT were measured by chemiluminescent method and RIA. A significant decrease in cytosol GR and Hsp 70 was observed after acute stress, while chronic stresses led to negligible changes in both these proteins and caused a reduced responsiveness to a novel acute stress. This was valid irrespective of the type of chronic or acute stress combinations for both hippocampal and cortical GR and Hsp 70. The results support the hypothesis that chronic stress-induced deregulation of the LHPA axis may be caused, at least in part, by partial disruption of intracelullar negative feedback control in the higher centers of the brain. Copyright (C) 2005 S. Karger AG, Basel.
T2 - Neuropsychobiology
T1 - Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress
VL - 51
IS - 2
SP - 107
EP - 114
DO - 10.1159/000084168
ER -
@article{
author = "Filipović, Dragana and Gavrilović, Ljubica and Dronjak, Slađana and Radojčić, Marija",
year = "2005",
abstract = "The pattern and intensity of glucocorticoid receptor (GR) and heat shock 70 protein (Hsp 70) changes in the hippocampus and brain cortex of adult Wistar rat males exposed to acute (immobilization, cold) and chronic (social isolation, crowding, daily swimming) stress or their combinations were followed by Western immunoblotting. Plasma ACTH and CORT were measured by chemiluminescent method and RIA. A significant decrease in cytosol GR and Hsp 70 was observed after acute stress, while chronic stresses led to negligible changes in both these proteins and caused a reduced responsiveness to a novel acute stress. This was valid irrespective of the type of chronic or acute stress combinations for both hippocampal and cortical GR and Hsp 70. The results support the hypothesis that chronic stress-induced deregulation of the LHPA axis may be caused, at least in part, by partial disruption of intracelullar negative feedback control in the higher centers of the brain. Copyright (C) 2005 S. Karger AG, Basel.",
journal = "Neuropsychobiology",
title = "Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress",
volume = "51",
number = "2",
pages = "107-114",
doi = "10.1159/000084168"
}
Filipović, D., Gavrilović, L., Dronjak, S.,& Radojčić, M.. (2005). Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress. in Neuropsychobiology, 51(2), 107-114.
https://doi.org/10.1159/000084168
Filipović D, Gavrilović L, Dronjak S, Radojčić M. Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress. in Neuropsychobiology. 2005;51(2):107-114.
doi:10.1159/000084168 .
Filipović, Dragana, Gavrilović, Ljubica, Dronjak, Slađana, Radojčić, Marija, "Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress" in Neuropsychobiology, 51, no. 2 (2005):107-114,
https://doi.org/10.1159/000084168 . .
