Investigation of complex equilibria in solutions of p-aminohippuric acid and tin (II) ion in perchlorate medium
Abstract
The complex equilibrium in tin (II)-p-aminohippuric acid (PAH) solutions in perchlorate medium was investigated. The interaction between Sn (II)-ion and PAH was studied with the purpose to establish whether PAH could form complex with, Sn (II)-ion during the labeling with technetium-99m. HPLC, spectrophotometric and pH-metric methods were used. Dissociation constants of PAH, thermodynamic parameters of PAH dissociation, as well as stability constant of tin (II)-PAH were determined. The values of thermodynamic dissociation constants of PAH were 4.25, 4.19 and 4.15 at 295, 302 and 310 K respectively. The calculated thermodynamic values DeltaGdegrees, DeltaHdegrees and DeltaSdegrees, were -24.01 KJ mol(-1), -12.44 KJ mol(-1) and 39.22 Jmol(-1) K-1 at 295 K respectively. Sn (II)-ion exhibits only a weak interaction with PAH in the pH range 2.0 divided by 3.7, e.g. in the Sn-PAH solution a weak complex with high degree of dissociation was obtained. The treatment of spectral data referring t...o Sn-PAH solutions indicates the formation of a mononuclear complex [SnPAH](+). Mathematical analysis of experimental data indicated that the best fit of the potentiometric data was achieved by assuming the formation of a mixed hydrolytic complex [Sn(OH)PAH]. The calculated value of the stability constant was: log beta(1,-1.1) = 0.95 +/- 0.11 at 298 K.
Keywords:
PAH / dissociation constant / Sn (II)-ion / complex formationSource:
Reviews in Analytical Chemistry, 2004, 23, 2, 87-105Collections
Institution/Community
VinčaTY - JOUR AU - Janković, Drina AU - Đokić, Divna Đ. PY - 2004 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2850 AB - The complex equilibrium in tin (II)-p-aminohippuric acid (PAH) solutions in perchlorate medium was investigated. The interaction between Sn (II)-ion and PAH was studied with the purpose to establish whether PAH could form complex with, Sn (II)-ion during the labeling with technetium-99m. HPLC, spectrophotometric and pH-metric methods were used. Dissociation constants of PAH, thermodynamic parameters of PAH dissociation, as well as stability constant of tin (II)-PAH were determined. The values of thermodynamic dissociation constants of PAH were 4.25, 4.19 and 4.15 at 295, 302 and 310 K respectively. The calculated thermodynamic values DeltaGdegrees, DeltaHdegrees and DeltaSdegrees, were -24.01 KJ mol(-1), -12.44 KJ mol(-1) and 39.22 Jmol(-1) K-1 at 295 K respectively. Sn (II)-ion exhibits only a weak interaction with PAH in the pH range 2.0 divided by 3.7, e.g. in the Sn-PAH solution a weak complex with high degree of dissociation was obtained. The treatment of spectral data referring to Sn-PAH solutions indicates the formation of a mononuclear complex [SnPAH](+). Mathematical analysis of experimental data indicated that the best fit of the potentiometric data was achieved by assuming the formation of a mixed hydrolytic complex [Sn(OH)PAH]. The calculated value of the stability constant was: log beta(1,-1.1) = 0.95 +/- 0.11 at 298 K. T2 - Reviews in Analytical Chemistry T1 - Investigation of complex equilibria in solutions of p-aminohippuric acid and tin (II) ion in perchlorate medium VL - 23 IS - 2 SP - 87 EP - 105 UR - https://hdl.handle.net/21.15107/rcub_vinar_2850 ER -
@article{ author = "Janković, Drina and Đokić, Divna Đ.", year = "2004", abstract = "The complex equilibrium in tin (II)-p-aminohippuric acid (PAH) solutions in perchlorate medium was investigated. The interaction between Sn (II)-ion and PAH was studied with the purpose to establish whether PAH could form complex with, Sn (II)-ion during the labeling with technetium-99m. HPLC, spectrophotometric and pH-metric methods were used. Dissociation constants of PAH, thermodynamic parameters of PAH dissociation, as well as stability constant of tin (II)-PAH were determined. The values of thermodynamic dissociation constants of PAH were 4.25, 4.19 and 4.15 at 295, 302 and 310 K respectively. The calculated thermodynamic values DeltaGdegrees, DeltaHdegrees and DeltaSdegrees, were -24.01 KJ mol(-1), -12.44 KJ mol(-1) and 39.22 Jmol(-1) K-1 at 295 K respectively. Sn (II)-ion exhibits only a weak interaction with PAH in the pH range 2.0 divided by 3.7, e.g. in the Sn-PAH solution a weak complex with high degree of dissociation was obtained. The treatment of spectral data referring to Sn-PAH solutions indicates the formation of a mononuclear complex [SnPAH](+). Mathematical analysis of experimental data indicated that the best fit of the potentiometric data was achieved by assuming the formation of a mixed hydrolytic complex [Sn(OH)PAH]. The calculated value of the stability constant was: log beta(1,-1.1) = 0.95 +/- 0.11 at 298 K.", journal = "Reviews in Analytical Chemistry", title = "Investigation of complex equilibria in solutions of p-aminohippuric acid and tin (II) ion in perchlorate medium", volume = "23", number = "2", pages = "87-105", url = "https://hdl.handle.net/21.15107/rcub_vinar_2850" }
Janković, D.,& Đokić, D. Đ.. (2004). Investigation of complex equilibria in solutions of p-aminohippuric acid and tin (II) ion in perchlorate medium. in Reviews in Analytical Chemistry, 23(2), 87-105. https://hdl.handle.net/21.15107/rcub_vinar_2850
Janković D, Đokić DĐ. Investigation of complex equilibria in solutions of p-aminohippuric acid and tin (II) ion in perchlorate medium. in Reviews in Analytical Chemistry. 2004;23(2):87-105. https://hdl.handle.net/21.15107/rcub_vinar_2850 .
Janković, Drina, Đokić, Divna Đ., "Investigation of complex equilibria in solutions of p-aminohippuric acid and tin (II) ion in perchlorate medium" in Reviews in Analytical Chemistry, 23, no. 2 (2004):87-105, https://hdl.handle.net/21.15107/rcub_vinar_2850 .