Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid
Apstrakt
In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. (C) 2004 Elsevier B.V. All rights reserved.
Ključne reči:
iminodiacetic acid / METHYLIODIDA / ionization constants / potentiometryIzvor:
Journal of Pharmaceutical and Biomedical Analysis, 2004, 35, 5, 1257-1261
DOI: 10.1016/j.jpba.2004.03.009
ISSN: 0731-7085
PubMed: 15336370
WoS: 000224261500027
Scopus: 2-s2.0-4344623397
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Jovanović, Moma S. AU - Popovic, G AU - Kapetanovic, V AU - Orlić, Milan P. AU - Vladimirov, Sote PY - 2004 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2811 AB - In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. (C) 2004 Elsevier B.V. All rights reserved. T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid VL - 35 IS - 5 SP - 1257 EP - 1261 DO - 10.1016/j.jpba.2004.03.009 ER -
@article{ author = "Jovanović, Moma S. and Popovic, G and Kapetanovic, V and Orlić, Milan P. and Vladimirov, Sote", year = "2004", abstract = "In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. (C) 2004 Elsevier B.V. All rights reserved.", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid", volume = "35", number = "5", pages = "1257-1261", doi = "10.1016/j.jpba.2004.03.009" }
Jovanović, M. S., Popovic, G., Kapetanovic, V., Orlić, M. P.,& Vladimirov, S.. (2004). Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis, 35(5), 1257-1261. https://doi.org/10.1016/j.jpba.2004.03.009
Jovanović MS, Popovic G, Kapetanovic V, Orlić MP, Vladimirov S. Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis. 2004;35(5):1257-1261. doi:10.1016/j.jpba.2004.03.009 .
Jovanović, Moma S., Popovic, G, Kapetanovic, V, Orlić, Milan P., Vladimirov, Sote, "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid" in Journal of Pharmaceutical and Biomedical Analysis, 35, no. 5 (2004):1257-1261, https://doi.org/10.1016/j.jpba.2004.03.009 . .