Recombination property of the HIV-1 gp120 gene
Апстракт
Using a chimeric primer consisting of the nucleotide sequence derived from the HIV-1 envelope gene coding for the second conserved region of gp120, and the highly conserved sequence derived from the human immunoglobulin gene coding for the VHIII domain, it has been identified in sera of AIDS patients HIV-1 field isolates carrying the complete and active Chi recombination hot spot (GCTGGTGG). The recombination between the HIV-1 gene coding for the central portion of gp120 and the bacterial gene coding for the clp protease was also demonstrated in vivo. These results point out serious concern that vectored AIDS vaccine candidates carrying the HIV-1 env gene on viral and bacterial vectors could become the source of potentially new infectious diseases rather than an effective instrument for AIDS prevention.
Кључне речи:
HIV-1 gp120 gene / Chi / homologous recombination / AIDS vaccine / safetyИзвор:
International Reviews of Immunology, 2004, 23, 5-6, 447-454
DOI: 10.1080/08830180490432839
ISSN: 0883-0185
PubMed: 15370276
WoS: 000223983900007
Scopus: 2-s2.0-4644291231
Колекције
Институција/група
VinčaTY - JOUR AU - Prljić, Jelena AU - Veljković, Nevena V. AU - Veljković, Veljko PY - 2004 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2808 AB - Using a chimeric primer consisting of the nucleotide sequence derived from the HIV-1 envelope gene coding for the second conserved region of gp120, and the highly conserved sequence derived from the human immunoglobulin gene coding for the VHIII domain, it has been identified in sera of AIDS patients HIV-1 field isolates carrying the complete and active Chi recombination hot spot (GCTGGTGG). The recombination between the HIV-1 gene coding for the central portion of gp120 and the bacterial gene coding for the clp protease was also demonstrated in vivo. These results point out serious concern that vectored AIDS vaccine candidates carrying the HIV-1 env gene on viral and bacterial vectors could become the source of potentially new infectious diseases rather than an effective instrument for AIDS prevention. T2 - International Reviews of Immunology T1 - Recombination property of the HIV-1 gp120 gene VL - 23 IS - 5-6 SP - 447 EP - 454 DO - 10.1080/08830180490432839 ER -
@article{ author = "Prljić, Jelena and Veljković, Nevena V. and Veljković, Veljko", year = "2004", abstract = "Using a chimeric primer consisting of the nucleotide sequence derived from the HIV-1 envelope gene coding for the second conserved region of gp120, and the highly conserved sequence derived from the human immunoglobulin gene coding for the VHIII domain, it has been identified in sera of AIDS patients HIV-1 field isolates carrying the complete and active Chi recombination hot spot (GCTGGTGG). The recombination between the HIV-1 gene coding for the central portion of gp120 and the bacterial gene coding for the clp protease was also demonstrated in vivo. These results point out serious concern that vectored AIDS vaccine candidates carrying the HIV-1 env gene on viral and bacterial vectors could become the source of potentially new infectious diseases rather than an effective instrument for AIDS prevention.", journal = "International Reviews of Immunology", title = "Recombination property of the HIV-1 gp120 gene", volume = "23", number = "5-6", pages = "447-454", doi = "10.1080/08830180490432839" }
Prljić, J., Veljković, N. V.,& Veljković, V.. (2004). Recombination property of the HIV-1 gp120 gene. in International Reviews of Immunology, 23(5-6), 447-454. https://doi.org/10.1080/08830180490432839
Prljić J, Veljković NV, Veljković V. Recombination property of the HIV-1 gp120 gene. in International Reviews of Immunology. 2004;23(5-6):447-454. doi:10.1080/08830180490432839 .
Prljić, Jelena, Veljković, Nevena V., Veljković, Veljko, "Recombination property of the HIV-1 gp120 gene" in International Reviews of Immunology, 23, no. 5-6 (2004):447-454, https://doi.org/10.1080/08830180490432839 . .