Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives
Апстракт
The confirmation that N-substituted imidodiacetic acids, as small and simple ligand systems containing amines and carboxylic acids, could be coordinated to the tricarbonyl core and form inert complexes with [Tc-99m (CO)(3)(H2O)(3)](+). is demonstrated. The HPLC quality control results of Tc-99m-carbonyl tagged IDA molecules, performed by gradient HPLC, have shown that HIDA, EHIDA and p-butyl-IDA form complexes with [Tc-99m(CO)(3)(H2O)(3)](+), with a labeling yield of similar to90% for each of Tc-99m(CO)(3) IDA derivatives. However, the changes in the structure of labeled compounds, e.g., EHIDA, influence the changes in the biological behavior. In comparison with Tc-99m-EHIDA, the biliary excretion of Tc-99m(CO)(3) EHIDA was lower, but the urinary excretion higher.
Извор:
Journal of Radioanalytical and Nuclear Chemistry, 2004, 260, 3, 471-476
DOI: 10.1023/B:JRNC.0000028204.03708.89
ISSN: 0236-5731
WoS: 000221479900005
Scopus: 2-s2.0-3543140231
Колекције
Институција/група
VinčaTY - JOUR AU - Đokić, Divna Đ. AU - Janković, Drina AU - Stamenkovic, LL AU - Pirmettis, Ioannis PY - 2004 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2770 AB - The confirmation that N-substituted imidodiacetic acids, as small and simple ligand systems containing amines and carboxylic acids, could be coordinated to the tricarbonyl core and form inert complexes with [Tc-99m (CO)(3)(H2O)(3)](+). is demonstrated. The HPLC quality control results of Tc-99m-carbonyl tagged IDA molecules, performed by gradient HPLC, have shown that HIDA, EHIDA and p-butyl-IDA form complexes with [Tc-99m(CO)(3)(H2O)(3)](+), with a labeling yield of similar to90% for each of Tc-99m(CO)(3) IDA derivatives. However, the changes in the structure of labeled compounds, e.g., EHIDA, influence the changes in the biological behavior. In comparison with Tc-99m-EHIDA, the biliary excretion of Tc-99m(CO)(3) EHIDA was lower, but the urinary excretion higher. T2 - Journal of Radioanalytical and Nuclear Chemistry T1 - Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives VL - 260 IS - 3 SP - 471 EP - 476 DO - 10.1023/B:JRNC.0000028204.03708.89 ER -
@article{ author = "Đokić, Divna Đ. and Janković, Drina and Stamenkovic, LL and Pirmettis, Ioannis", year = "2004", abstract = "The confirmation that N-substituted imidodiacetic acids, as small and simple ligand systems containing amines and carboxylic acids, could be coordinated to the tricarbonyl core and form inert complexes with [Tc-99m (CO)(3)(H2O)(3)](+). is demonstrated. The HPLC quality control results of Tc-99m-carbonyl tagged IDA molecules, performed by gradient HPLC, have shown that HIDA, EHIDA and p-butyl-IDA form complexes with [Tc-99m(CO)(3)(H2O)(3)](+), with a labeling yield of similar to90% for each of Tc-99m(CO)(3) IDA derivatives. However, the changes in the structure of labeled compounds, e.g., EHIDA, influence the changes in the biological behavior. In comparison with Tc-99m-EHIDA, the biliary excretion of Tc-99m(CO)(3) EHIDA was lower, but the urinary excretion higher.", journal = "Journal of Radioanalytical and Nuclear Chemistry", title = "Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives", volume = "260", number = "3", pages = "471-476", doi = "10.1023/B:JRNC.0000028204.03708.89" }
Đokić, D. Đ., Janković, D., Stamenkovic, L.,& Pirmettis, I.. (2004). Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry, 260(3), 471-476. https://doi.org/10.1023/B:JRNC.0000028204.03708.89
Đokić DĐ, Janković D, Stamenkovic L, Pirmettis I. Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry. 2004;260(3):471-476. doi:10.1023/B:JRNC.0000028204.03708.89 .
Đokić, Divna Đ., Janković, Drina, Stamenkovic, LL, Pirmettis, Ioannis, "Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives" in Journal of Radioanalytical and Nuclear Chemistry, 260, no. 3 (2004):471-476, https://doi.org/10.1023/B:JRNC.0000028204.03708.89 . .