Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives
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The confirmation that N-substituted imidodiacetic acids, as small and simple ligand systems containing amines and carboxylic acids, could be coordinated to the tricarbonyl core and form inert complexes with [Tc-99m (CO)(3)(H2O)(3)](+). is demonstrated. The HPLC quality control results of Tc-99m-carbonyl tagged IDA molecules, performed by gradient HPLC, have shown that HIDA, EHIDA and p-butyl-IDA form complexes with [Tc-99m(CO)(3)(H2O)(3)](+), with a labeling yield of similar to90% for each of Tc-99m(CO)(3) IDA derivatives. However, the changes in the structure of labeled compounds, e.g., EHIDA, influence the changes in the biological behavior. In comparison with Tc-99m-EHIDA, the biliary excretion of Tc-99m(CO)(3) EHIDA was lower, but the urinary excretion higher.