High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats
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Autori
Rašić-Marković, AleksandraĐurić, Dragan M.
Hrnčić, Dragan
Lončar-Stevanović, Helena
Vucevic, Danijela
Mladenovic, Dusan
Brkić, Predrag
Djuro, Macut
Stanojević, Ivana
Stanojlović, Olivera
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The effects of ethanol on epilepsy are very complex. Ethanol can have depressant as well as excitatory effect on different animal models of epilepsy. Systemic administration of homocysteine can trigger seizures. The aim of the present study was to examine the changes of total spectral power density after ethanol alone and together with homocysteine thiolactone in adult rats. Adult male Wistar rats were divided into following groups: I. saline-injected, (control) C; 2. D, L-homocysteine thiolactone, H (8 mmol/kg); 3. ethanol, E (E(0.5), 0.5 g/kg; E(1), 1 g/kg; E(2), 2 g/kg) and 4. E (E(0.5), E(1), and E(2)) 30 min prior to H, EH (E(0.5)H, E(1)H and E(2)H). For EEG recordings three gold-plated screws were implanted into the skull. Our results demonstrate that ethanol, when applied alone, increased total EEG spectral power density of adult rats with a marked spectrum shift toward low frequency waves. In EH groups, increasing doses of ethanol exhibited a dose-dependent effect upon spectral... power density. Ethanol increased EEG spectral power density in E(0.5)H and E(1)H group, comparing to the H group (p GT 0.05), the maximal increase was recorded with the lowest ethanol dose applied. The highest dose of ethanol (E(2)H) significantly decreased total power spectra density, comparing to the H group. We can conclude that high doses of ethanol depressed marked increase in EEG power spectrum induced by D,L-homocysteine thiolactone.
Ključne reči:
Epilepsy / EEG / Ethanol / D,L-homocysteine thiolactoneIzvor:
General Physiology and Biophysics, 2009, 28, SI, 25-32Finansiranje / projekti:
- Ministry for Science, Technology and Environmental Protection of Serbia [145 029B]
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Institucija/grupa
VinčaTY - JOUR AU - Rašić-Marković, Aleksandra AU - Đurić, Dragan M. AU - Hrnčić, Dragan AU - Lončar-Stevanović, Helena AU - Vucevic, Danijela AU - Mladenovic, Dusan AU - Brkić, Predrag AU - Djuro, Macut AU - Stanojević, Ivana AU - Stanojlović, Olivera PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2729 AB - The effects of ethanol on epilepsy are very complex. Ethanol can have depressant as well as excitatory effect on different animal models of epilepsy. Systemic administration of homocysteine can trigger seizures. The aim of the present study was to examine the changes of total spectral power density after ethanol alone and together with homocysteine thiolactone in adult rats. Adult male Wistar rats were divided into following groups: I. saline-injected, (control) C; 2. D, L-homocysteine thiolactone, H (8 mmol/kg); 3. ethanol, E (E(0.5), 0.5 g/kg; E(1), 1 g/kg; E(2), 2 g/kg) and 4. E (E(0.5), E(1), and E(2)) 30 min prior to H, EH (E(0.5)H, E(1)H and E(2)H). For EEG recordings three gold-plated screws were implanted into the skull. Our results demonstrate that ethanol, when applied alone, increased total EEG spectral power density of adult rats with a marked spectrum shift toward low frequency waves. In EH groups, increasing doses of ethanol exhibited a dose-dependent effect upon spectral power density. Ethanol increased EEG spectral power density in E(0.5)H and E(1)H group, comparing to the H group (p GT 0.05), the maximal increase was recorded with the lowest ethanol dose applied. The highest dose of ethanol (E(2)H) significantly decreased total power spectra density, comparing to the H group. We can conclude that high doses of ethanol depressed marked increase in EEG power spectrum induced by D,L-homocysteine thiolactone. T2 - General Physiology and Biophysics T1 - High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats VL - 28 IS - SI SP - 25 EP - 32 UR - https://hdl.handle.net/21.15107/rcub_vinar_2729 ER -
@article{ author = "Rašić-Marković, Aleksandra and Đurić, Dragan M. and Hrnčić, Dragan and Lončar-Stevanović, Helena and Vucevic, Danijela and Mladenovic, Dusan and Brkić, Predrag and Djuro, Macut and Stanojević, Ivana and Stanojlović, Olivera", year = "2009", abstract = "The effects of ethanol on epilepsy are very complex. Ethanol can have depressant as well as excitatory effect on different animal models of epilepsy. Systemic administration of homocysteine can trigger seizures. The aim of the present study was to examine the changes of total spectral power density after ethanol alone and together with homocysteine thiolactone in adult rats. Adult male Wistar rats were divided into following groups: I. saline-injected, (control) C; 2. D, L-homocysteine thiolactone, H (8 mmol/kg); 3. ethanol, E (E(0.5), 0.5 g/kg; E(1), 1 g/kg; E(2), 2 g/kg) and 4. E (E(0.5), E(1), and E(2)) 30 min prior to H, EH (E(0.5)H, E(1)H and E(2)H). For EEG recordings three gold-plated screws were implanted into the skull. Our results demonstrate that ethanol, when applied alone, increased total EEG spectral power density of adult rats with a marked spectrum shift toward low frequency waves. In EH groups, increasing doses of ethanol exhibited a dose-dependent effect upon spectral power density. Ethanol increased EEG spectral power density in E(0.5)H and E(1)H group, comparing to the H group (p GT 0.05), the maximal increase was recorded with the lowest ethanol dose applied. The highest dose of ethanol (E(2)H) significantly decreased total power spectra density, comparing to the H group. We can conclude that high doses of ethanol depressed marked increase in EEG power spectrum induced by D,L-homocysteine thiolactone.", journal = "General Physiology and Biophysics", title = "High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats", volume = "28", number = "SI", pages = "25-32", url = "https://hdl.handle.net/21.15107/rcub_vinar_2729" }
Rašić-Marković, A., Đurić, D. M., Hrnčić, D., Lončar-Stevanović, H., Vucevic, D., Mladenovic, D., Brkić, P., Djuro, M., Stanojević, I.,& Stanojlović, O.. (2009). High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats. in General Physiology and Biophysics, 28(SI), 25-32. https://hdl.handle.net/21.15107/rcub_vinar_2729
Rašić-Marković A, Đurić DM, Hrnčić D, Lončar-Stevanović H, Vucevic D, Mladenovic D, Brkić P, Djuro M, Stanojević I, Stanojlović O. High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats. in General Physiology and Biophysics. 2009;28(SI):25-32. https://hdl.handle.net/21.15107/rcub_vinar_2729 .
Rašić-Marković, Aleksandra, Đurić, Dragan M., Hrnčić, Dragan, Lončar-Stevanović, Helena, Vucevic, Danijela, Mladenovic, Dusan, Brkić, Predrag, Djuro, Macut, Stanojević, Ivana, Stanojlović, Olivera, "High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats" in General Physiology and Biophysics, 28, no. SI (2009):25-32, https://hdl.handle.net/21.15107/rcub_vinar_2729 .