Baseline micronuclei in fetal lymphocytes-a higher frequency in females relative to males
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This study provides information concerning base-line micronuclei (MN) and sister-chromatid exchanges (SCEs) in human-fetal lymphocytes. Fetal cord blood (75 samples) were used for purposes of prenatal diagnosis; small aliquots of each were set up into cultures for micronuclei and sister-chromatid exchage analysis. Obtained mean values of base-line MN in fetal lymphocytes are 21.48 +/- 3.52 for males, 24.54 +/- 5.31 for females, respectively. Although small number of fetuses carrying abnormal karyotype was found (6 out of 75), no statistical difference in base-line level of micronuclei between normal versus abnormal karyotype was found. The mean value of SCE is 4.06 +/- 0.77 in female group, 4.03 +/- 0.66 in male group, respectively. As in the case of base-line micronuclei in fetal lymphocytes carrying abnormal karyotype SCEs also are not affected by chromosomal imbalances. There was a lack of correlation between MN and SCE incidence (r = 0.12).