Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease
Nema prikaza
Autori
Veljković, Nevena V.Branch, DR
Metlaš, Radmila
Prljić, Jelena
Vlahovicek, K
Pongor, S
Veljković, Veljko
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
It has been reported that the C-terminus of the second conserved region (C2) of the envelope glycoprotein gp120, encompassing peptide RSANFTDNAKTIIVQLNESVEIN (NTM), is important for infectivity and neutralization of the human immunodeficiency virus type 1 (HIV-1). It was also demonstrated that human natural anti-vasoactive intestinal peptide (VIP) antibodies reactive with this gp120 region play an important role in control of HIV disease progression. The bioinformatic analysis based on the time-frequency signal processing revealed non-obvious similarities between NTM and VIP. When tested against a battery of sera from 46 AIDS patients, these peptides, in spite of a significant difference in their primary structures, showed a similar reactivity profiles (r = 0.83). Presented results point out that similarity in the periodical pattern of some physicochemical properties in primary structures of peptides plays a significant role in determination of their immunological crossreactivity. Base...d on these findings, we propose this bioinformatic criterion be used for design of VIP/NTM peptide mimetics for prevention and treatment of HIV disease.
Ključne reči:
drug design / gp120 / HIV-1 / peptide mimeticIzvor:
Journal of Peptide Research, 2003, 62, 4, 158-166
DOI: 10.1034/j.1399-3011.2003.00081.x
ISSN: 1397-002X
PubMed: 12969195
WoS: 000186984100002
Scopus: 2-s2.0-0141727804
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Institucija/grupa
VinčaTY - JOUR AU - Veljković, Nevena V. AU - Branch, DR AU - Metlaš, Radmila AU - Prljić, Jelena AU - Vlahovicek, K AU - Pongor, S AU - Veljković, Veljko PY - 2003 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2693 AB - It has been reported that the C-terminus of the second conserved region (C2) of the envelope glycoprotein gp120, encompassing peptide RSANFTDNAKTIIVQLNESVEIN (NTM), is important for infectivity and neutralization of the human immunodeficiency virus type 1 (HIV-1). It was also demonstrated that human natural anti-vasoactive intestinal peptide (VIP) antibodies reactive with this gp120 region play an important role in control of HIV disease progression. The bioinformatic analysis based on the time-frequency signal processing revealed non-obvious similarities between NTM and VIP. When tested against a battery of sera from 46 AIDS patients, these peptides, in spite of a significant difference in their primary structures, showed a similar reactivity profiles (r = 0.83). Presented results point out that similarity in the periodical pattern of some physicochemical properties in primary structures of peptides plays a significant role in determination of their immunological crossreactivity. Based on these findings, we propose this bioinformatic criterion be used for design of VIP/NTM peptide mimetics for prevention and treatment of HIV disease. T2 - Journal of Peptide Research T1 - Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease VL - 62 IS - 4 SP - 158 EP - 166 DO - 10.1034/j.1399-3011.2003.00081.x ER -
@article{ author = "Veljković, Nevena V. and Branch, DR and Metlaš, Radmila and Prljić, Jelena and Vlahovicek, K and Pongor, S and Veljković, Veljko", year = "2003", abstract = "It has been reported that the C-terminus of the second conserved region (C2) of the envelope glycoprotein gp120, encompassing peptide RSANFTDNAKTIIVQLNESVEIN (NTM), is important for infectivity and neutralization of the human immunodeficiency virus type 1 (HIV-1). It was also demonstrated that human natural anti-vasoactive intestinal peptide (VIP) antibodies reactive with this gp120 region play an important role in control of HIV disease progression. The bioinformatic analysis based on the time-frequency signal processing revealed non-obvious similarities between NTM and VIP. When tested against a battery of sera from 46 AIDS patients, these peptides, in spite of a significant difference in their primary structures, showed a similar reactivity profiles (r = 0.83). Presented results point out that similarity in the periodical pattern of some physicochemical properties in primary structures of peptides plays a significant role in determination of their immunological crossreactivity. Based on these findings, we propose this bioinformatic criterion be used for design of VIP/NTM peptide mimetics for prevention and treatment of HIV disease.", journal = "Journal of Peptide Research", title = "Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease", volume = "62", number = "4", pages = "158-166", doi = "10.1034/j.1399-3011.2003.00081.x" }
Veljković, N. V., Branch, D., Metlaš, R., Prljić, J., Vlahovicek, K., Pongor, S.,& Veljković, V.. (2003). Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease. in Journal of Peptide Research, 62(4), 158-166. https://doi.org/10.1034/j.1399-3011.2003.00081.x
Veljković NV, Branch D, Metlaš R, Prljić J, Vlahovicek K, Pongor S, Veljković V. Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease. in Journal of Peptide Research. 2003;62(4):158-166. doi:10.1034/j.1399-3011.2003.00081.x .
Veljković, Nevena V., Branch, DR, Metlaš, Radmila, Prljić, Jelena, Vlahovicek, K, Pongor, S, Veljković, Veljko, "Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease" in Journal of Peptide Research, 62, no. 4 (2003):158-166, https://doi.org/10.1034/j.1399-3011.2003.00081.x . .