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Elevated plasma levels of transforming growth factor-beta(1) (TGF-beta(1)) in patients with advanced breast cancer: association with disease progression
dc.creator | Ivanović, Vesna | |
dc.creator | Todorović-Raković, N | |
dc.creator | Demajo, Miroslav | |
dc.creator | Nešković-Konstantinović, Zora | |
dc.creator | Subota, Vesna | |
dc.creator | Ivanišević-Milovanović, Olivera | |
dc.creator | Nikolić-Vukosavljević, Dragica | |
dc.date.accessioned | 2018-03-01T19:14:59Z | |
dc.date.available | 2018-03-01T19:14:59Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0959-8049 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2617 | |
dc.description.abstract | We examined the association between an elevated plasma TGF-beta(1) level and the disease progression of advanced breast cancer (BC) patients (n = 44). TGF-beta(1) levels were detected by an enzyme-linked immunosorbent assay (ELISA). Platelet carryover and in vitro platelet activation in our plasma samples was assessed and found to be insignificant. Plasma TGF-beta(1) values were significantly elevated (P LT 0.05) in stage IIIB/IV patients (median value: 2.40 ng/ml, range: 0.13-8.48 ng/ml, n=44) compared with healthy donors (median value: 1.30 ng/ml, range: 0.41-4.93 ng/ml, n=36). Although pronounced in metastatic patients, especially those who had been newly diagnosed, TGF- and beta;(1) elevation was independent of tumour mass, site of distant metastases, histopathological type, steroid receptor (SR) content and age of the BC patients. Follow-up of 6 patients indicated a relationship between the plasma TGF- and beta;(1) and the patients response. This suggests that TGF- and beta;(1), may be a promising prognostic marker for breast cancer patients with advanced disease. Confirmatory large-scale studies are needed, particularly given the overlap of values between our different subgroups analysed. | en |
dc.relation | Ministry of Sciences, Technology and Development of the Republic of Serbia [projects Nos. 1598 and 2019] | |
dc.rights | restrictedAccess | en |
dc.source | European Journal of Cancer | en |
dc.subject | TGF-beta(1) | en |
dc.subject | platelet factor 4 | en |
dc.subject | human plasma | en |
dc.subject | prognostic biomarker(s) | en |
dc.subject | breast cancer progression | en |
dc.title | Elevated plasma levels of transforming growth factor-beta(1) (TGF-beta(1)) in patients with advanced breast cancer: association with disease progression | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Ивановиц, В; Тодоровиц-Раковиц, Н; Демајо, М; Несковиц-Константиновиц, З; Субота, В; Иванисевиц-Миловановиц, О; Николиц-Вукосављевиц, Д; | |
dc.citation.volume | 39 | |
dc.citation.issue | 4 | |
dc.citation.spage | 454 | |
dc.citation.epage | 461 | |
dc.identifier.wos | 000181686800017 | |
dc.identifier.doi | 10.1016/S0959-8049(02)00502-6 | |
dc.citation.other | Article Number: PII S0959-8049(02)00502-6 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 12751375 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-0037363281 |