dc.creator | Stanković, Aleksandra | |
dc.creator | Živković, Maja | |
dc.creator | Alavantić, Dragan | |
dc.date.accessioned | 2018-03-01T19:11:53Z | |
dc.date.available | 2018-03-01T19:11:53Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0036-5513 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2582 | |
dc.description.abstract | Human essential hypertension has a multifactorial origin and is caused by a delicate interaction between susceptibility genes and environmental factors. Candidate genes are selected from the renin-angiotensin system (RAS) and are physiologically implicated in blood pressure regulation. We investigated the association between insertion/deletion (I/D) polymorphism at the angiotensin-converting enzyme (ACE) locus and hypertension in a case-control study conducted in a population of Caucasians (175 females, 210 males). Case subjects were those with untreated borderline hypertension. A significant, moderate, male, gender-specific independent association between DD genotype and high blood pressure was found. Adjusted odds ratio (OR) was 2.0 (95% Cl, 1.1 to 3.9; p = 0.03) in the whole group and 2.5 (95% CL 1.2 to 5.1; p = 0.01) in the group truncated on the basis of age (less than or equal to 50 years). Our findings support the hypothesis that ACE is a gender-specific candidate gene for hypertension. | en |
dc.rights | restrictedAccess | en |
dc.source | Scandinavian Journal of Clinical and Laboratory Investigation | en |
dc.subject | angiotensin | en |
dc.subject | DNA polymorphism | en |
dc.subject | gender | en |
dc.subject | hypertension | en |
dc.subject | population | en |
dc.title | Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension | en |
dc.type | article | en |
dcterms.abstract | Станковић Aлександра; Живковић Маја; Aлавантић Драган; | |
dc.citation.volume | 62 | |
dc.citation.issue | 6 | |
dc.citation.spage | 469 | |
dc.citation.epage | 475 | |
dc.identifier.wos | 000179228200008 | |
dc.identifier.doi | 10.1080/00365510260390028 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 12469902 | |
dc.identifier.scopus | 2-s2.0-0036428807 | |