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dc.creatorStanković, Aleksandra
dc.creatorŽivković, Maja
dc.creatorAlavantić, Dragan
dc.date.accessioned2018-03-01T19:11:53Z
dc.date.available2018-03-01T19:11:53Z
dc.date.issued2002
dc.identifier.issn0036-5513
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2582
dc.description.abstractHuman essential hypertension has a multifactorial origin and is caused by a delicate interaction between susceptibility genes and environmental factors. Candidate genes are selected from the renin-angiotensin system (RAS) and are physiologically implicated in blood pressure regulation. We investigated the association between insertion/deletion (I/D) polymorphism at the angiotensin-converting enzyme (ACE) locus and hypertension in a case-control study conducted in a population of Caucasians (175 females, 210 males). Case subjects were those with untreated borderline hypertension. A significant, moderate, male, gender-specific independent association between DD genotype and high blood pressure was found. Adjusted odds ratio (OR) was 2.0 (95% Cl, 1.1 to 3.9; p = 0.03) in the whole group and 2.5 (95% CL 1.2 to 5.1; p = 0.01) in the group truncated on the basis of age (less than or equal to 50 years). Our findings support the hypothesis that ACE is a gender-specific candidate gene for hypertension.en
dc.rightsrestrictedAccessen
dc.sourceScandinavian Journal of Clinical and Laboratory Investigationen
dc.subjectangiotensinen
dc.subjectDNA polymorphismen
dc.subjectgenderen
dc.subjecthypertensionen
dc.subjectpopulationen
dc.titleAngiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertensionen
dc.typearticleen
dcterms.abstractСтанковић Aлександра; Живковић Маја; Aлавантић Драган;
dc.citation.volume62
dc.citation.issue6
dc.citation.spage469
dc.citation.epage475
dc.identifier.wos000179228200008
dc.identifier.doi10.1080/00365510260390028
dc.citation.rankM23
dc.identifier.pmid12469902
dc.identifier.scopus2-s2.0-0036428807


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