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Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension

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Stanković, Aleksandra
Živković, Maja
Alavantić, Dragan
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Abstract
Human essential hypertension has a multifactorial origin and is caused by a delicate interaction between susceptibility genes and environmental factors. Candidate genes are selected from the renin-angiotensin system (RAS) and are physiologically implicated in blood pressure regulation. We investigated the association between insertion/deletion (I/D) polymorphism at the angiotensin-converting enzyme (ACE) locus and hypertension in a case-control study conducted in a population of Caucasians (175 females, 210 males). Case subjects were those with untreated borderline hypertension. A significant, moderate, male, gender-specific independent association between DD genotype and high blood pressure was found. Adjusted odds ratio (OR) was 2.0 (95% Cl, 1.1 to 3.9; p = 0.03) in the whole group and 2.5 (95% CL 1.2 to 5.1; p = 0.01) in the group truncated on the basis of age (less than or equal to 50 years). Our findings support the hypothesis that ACE is a gender-specific candidate gene for hyper...tension.

Keywords:
angiotensin / DNA polymorphism / gender / hypertension / population
Source:
Scandinavian Journal of Clinical and Laboratory Investigation, 2002, 62, 6, 469-475

DOI: 10.1080/00365510260390028

ISSN: 0036-5513 (print)

PubMed: 12469902

WoS: 000179228200008

Scopus: 2-s2.0-0036428807
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http://vinar.vin.bg.ac.rs/handle/123456789/2582
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