Chemical and biological properties of verapamil labeled with technetium-99m: A potential myocardial imaging agents
Само за регистроване кориснике
2002
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
On the base of property to enter into myocardial cells as a calcium channel blocker, verapamil was labeled with technetium-99m in order to investigate the possibility to obtain new radiopharmaceutical for myocardial imaging. The conditions of labeling verapamil with technetium-99m for different ammounts of stannous(II) ion, mannitol, cystein and pH range 2.5-3.5 were examined. Investigation of radiochemical purity ( GT 95%) and biodistribution of (9)9mTc-verapamil in rats showed that it was stable during 2 hours after labeling. Accumulation of Tc-99m-verapamil in heart was 1.2% and in liver 9.4%, 5 minutes after injection. Biodistribution of Tc-99m-verapamil in rats in conditions of stress, pharmacologically caused by dipiridamol, showed that the elimination of Tc-99m-verapamil from the heart was slower related to the control group. In the group of rats previously treated with isoproterenol uptake of Tc-99m-verapamil in heart was lower related to the control group (0.7% versus 1.0%) 5 ...minutes after injection. Lipophilicity of (9)9mTc-verapamil was examined by determination of partition coefficient (log P = 0.62) and protein binding (79%). Imaging studies on dogs provided relatively good myocardial images with partially overlap of activity in the lung and liver.
Извор:
Journal of Radioanalytical and Nuclear Chemistry, 2002, 253, 1, 81-86
DOI: 10.1023/A:1015864501284
ISSN: 0236-5731
WoS: 000176190300012
Scopus: 2-s2.0-0036063078
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Институција/група
VinčaTY - JOUR AU - Vranješ, Sanja AU - Jovanović, Moma S. AU - Prvulović, M. AU - Stefanović, L. AU - Kljajić, R. AU - Ratajac, R. PY - 2002 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2526 AB - On the base of property to enter into myocardial cells as a calcium channel blocker, verapamil was labeled with technetium-99m in order to investigate the possibility to obtain new radiopharmaceutical for myocardial imaging. The conditions of labeling verapamil with technetium-99m for different ammounts of stannous(II) ion, mannitol, cystein and pH range 2.5-3.5 were examined. Investigation of radiochemical purity ( GT 95%) and biodistribution of (9)9mTc-verapamil in rats showed that it was stable during 2 hours after labeling. Accumulation of Tc-99m-verapamil in heart was 1.2% and in liver 9.4%, 5 minutes after injection. Biodistribution of Tc-99m-verapamil in rats in conditions of stress, pharmacologically caused by dipiridamol, showed that the elimination of Tc-99m-verapamil from the heart was slower related to the control group. In the group of rats previously treated with isoproterenol uptake of Tc-99m-verapamil in heart was lower related to the control group (0.7% versus 1.0%) 5 minutes after injection. Lipophilicity of (9)9mTc-verapamil was examined by determination of partition coefficient (log P = 0.62) and protein binding (79%). Imaging studies on dogs provided relatively good myocardial images with partially overlap of activity in the lung and liver. T2 - Journal of Radioanalytical and Nuclear Chemistry T1 - Chemical and biological properties of verapamil labeled with technetium-99m: A potential myocardial imaging agents VL - 253 IS - 1 SP - 81 EP - 86 DO - 10.1023/A:1015864501284 ER -
@article{ author = "Vranješ, Sanja and Jovanović, Moma S. and Prvulović, M. and Stefanović, L. and Kljajić, R. and Ratajac, R.", year = "2002", abstract = "On the base of property to enter into myocardial cells as a calcium channel blocker, verapamil was labeled with technetium-99m in order to investigate the possibility to obtain new radiopharmaceutical for myocardial imaging. The conditions of labeling verapamil with technetium-99m for different ammounts of stannous(II) ion, mannitol, cystein and pH range 2.5-3.5 were examined. Investigation of radiochemical purity ( GT 95%) and biodistribution of (9)9mTc-verapamil in rats showed that it was stable during 2 hours after labeling. Accumulation of Tc-99m-verapamil in heart was 1.2% and in liver 9.4%, 5 minutes after injection. Biodistribution of Tc-99m-verapamil in rats in conditions of stress, pharmacologically caused by dipiridamol, showed that the elimination of Tc-99m-verapamil from the heart was slower related to the control group. In the group of rats previously treated with isoproterenol uptake of Tc-99m-verapamil in heart was lower related to the control group (0.7% versus 1.0%) 5 minutes after injection. Lipophilicity of (9)9mTc-verapamil was examined by determination of partition coefficient (log P = 0.62) and protein binding (79%). Imaging studies on dogs provided relatively good myocardial images with partially overlap of activity in the lung and liver.", journal = "Journal of Radioanalytical and Nuclear Chemistry", title = "Chemical and biological properties of verapamil labeled with technetium-99m: A potential myocardial imaging agents", volume = "253", number = "1", pages = "81-86", doi = "10.1023/A:1015864501284" }
Vranješ, S., Jovanović, M. S., Prvulović, M., Stefanović, L., Kljajić, R.,& Ratajac, R.. (2002). Chemical and biological properties of verapamil labeled with technetium-99m: A potential myocardial imaging agents. in Journal of Radioanalytical and Nuclear Chemistry, 253(1), 81-86. https://doi.org/10.1023/A:1015864501284
Vranješ S, Jovanović MS, Prvulović M, Stefanović L, Kljajić R, Ratajac R. Chemical and biological properties of verapamil labeled with technetium-99m: A potential myocardial imaging agents. in Journal of Radioanalytical and Nuclear Chemistry. 2002;253(1):81-86. doi:10.1023/A:1015864501284 .
Vranješ, Sanja, Jovanović, Moma S., Prvulović, M., Stefanović, L., Kljajić, R., Ratajac, R., "Chemical and biological properties of verapamil labeled with technetium-99m: A potential myocardial imaging agents" in Journal of Radioanalytical and Nuclear Chemistry, 253, no. 1 (2002):81-86, https://doi.org/10.1023/A:1015864501284 . .