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dc.creatorRoganović, Jelena
dc.creatorPetrović, Nina
dc.creatorĐukić, Ljiljana
dc.date.accessioned2018-03-01T15:30:00Z
dc.date.available2018-03-01T15:30:00Z
dc.date.issued2014
dc.identifier.issn0042-8450
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/251
dc.description.abstractBackground/Aim. Atherosclerotic-occlusive changes could be observed in orofacial branches of the external carotid artery. Atherosclerosis-induced ischemia caused alteration in production and release of endothelial factors. The aim of this study was to investigate the influence of carotid artery occlusion (10, 30 and 60 min) on vascular effects of norepincphrine (NOR) and neuropeptide Y (NPY) in the isolated glandular branch of the rabbit facial artery, the main feeding artery for the submandibular gland. Method. Changes in isometric tension were recorded in organ bath studies with arterial rings, before and after carotid artery occlusion. Results. Concentration-dependent vasocontractile effect of NOR was significantly augmented after 30 and 60 min of carotid occlusion, but only in the rings with intact endothelium. Given alone, NPY showed no effect in isolated glandular branch of the rabbit facial artery, but enhanced NOR vasoconstriction in all the investigated rings. NOR vasocontractilc effect enhancement in the presence of NPY was attenuated after 30 and 60 min of carotid occlusion. Also, enhancement of NOR vasoconstriction by NPY was significantly higher in endothelium-intact rings compared to endothelium-denuded rings obtained after 30 and 60 min of carotid occlusion. Conclusion. The present investigation provides results of increased vasocontractile effect of NOR and decreased enhancing effect of NPY on NOR vasoconstriction in the rabbit facial artery after carotid occlusion that is related to altered endothelium function.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175021/RS//
dc.rightsopenAccessen
dc.sourceVojnosanitetski pregleden
dc.subjectneuropeptidesen
dc.subjectnorepinephrineen
dc.subjectcarotid arteriesen
dc.subjectcarotid stenosisen
dc.subjectrabbitsen
dc.subjectvasoconstrictionen
dc.titleEffect of neuropeptide Y on norepinephrine-induced constriction in the rabbit facial artery after carotid artery occlusionen
dc.typearticleen
dcterms.abstractПетровић Нина; Дјукиц, Љиљана; Рогановиц, Јелена;
dc.citation.volume71
dc.citation.issue6
dc.citation.spage571
dc.citation.epage575
dc.identifier.wos000345813700008
dc.identifier.doi10.2298/VSP1406571R
dc.citation.rankM23
dc.identifier.pmid25039112
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-84903289098
dc.identifier.fulltexthttps://vinar.vin.bg.ac.rs//bitstream/id/12250/247.pdf


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