Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH
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The purpose of this study was to compare some physicochemical characteristics as well as pharmacokinetic behavior of Tc-99m-PAH as a novel renal agent, with Tc-99m-MAG(3) and (OIH)-O-131. Tc-99m-PAH was prepared from lyophilized kit by adding (TcO4-)-Tc-99m. Labeled complex was stabile and high radiochemical purity radiopharmaceutical, with a low percentage of protein bound to human albumin and hydrophilic character. In spite of its smaller renal uptake, Tc-99m-PAH gave satisfactory renal images. Tc-99m-PAH showed faster urinary elimination than Tc-99m-MAG(3) and similar to those one for I-131-OIH. The comparison of pharmacokinetic parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH indicated the favorable characteristics of Tc-99m-PAH.