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dc.creatorNedeljkovic, N
dc.creatorĐorđević, Vesna R.
dc.creatorHorvat, Anica
dc.creatorNikezic, G
dc.creatorKanazir, DT
dc.date.accessioned2018-03-01T18:53:43Z
dc.date.available2018-03-01T18:53:43Z
dc.date.issued2000
dc.identifier.issn0862-8408
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2376
dc.description.abstractAbundant evidence indicates that ATP and adenosine act as neurotransmitters or co-transmitters, influencing nerve cell physiology in various ways. Therefore, regulation of ATP-metabolizing enzymes is essential for the normal development and function of neuronal tissue. In the present study we have examined the effect of gonadal (OVX) or adrenal (ADX) steroid hormone deprivation on the activity and expression of synaptic membrane ecto-ATPase in three extrahypothalamic brain areas of female rats, primarily not associated with reproductive function. It was shown that OVX significantly increased ecto-ATPase activity and the relative abundance of this enzyme in the hippocampal (Hip) and caudate nucleus (CN), but not in brain stem (BS) membrane preparations. ADX was followed by an upregulation of the enzyme activity and its relative abundance in all the brain areas investigated. The highest enzyme activity and the most profound effects of OVX and ADX were detected in the CN. The results obtained indicate that ADX and OVX upregulate the expression of ecto-ATPase, potentiating the production of adenosine in synaptic cleft thus modulating the activity of numerous neurotransmitter systems in distinct areas of the CNS.en
dc.rightsrestrictedAccessen
dc.sourcePhysiological Researchen
dc.subjectecto-ATPaseen
dc.subjectovariectomyen
dc.subjectadrenalectomyen
dc.subjectextracellular nucleotidesen
dc.subjectrat brainen
dc.titleEffect of steroid hormone deprivation on the expression of ecto-ATPase in distinct brain regions of female ratsen
dc.typearticleen
dcterms.abstractНедељковиц, Н; Дјордјевиц, В; Никезиц, Г; Каназир, ДТ; Хорват, Aница;
dc.citation.volume49
dc.citation.issue4
dc.citation.spage419
dc.citation.epage426
dc.identifier.wos000089343600003
dc.citation.rankM23
dc.identifier.pmid11072801


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