UV derivative spectrophotometric study of the photochemical degradation of nisoldipine
Abstract
The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maxima...l degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively). (C) 2000 Elsevier Science S.A. All rights reserved.
Keywords:
nisoldipine / photodegradation / derivative UV spectrophotometrySource:
Il Farmaco, 2000, 55, 2, 128-133
DOI: 10.1016/S0014-827X(00)00004-5
ISSN: 0014-827X
PubMed: 10782384
WoS: 000086306600009
Scopus: 2-s2.0-0034063177
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VinčaTY - JOUR AU - Marinkovic, V AU - Agbaba, Danica AU - Karljiković-Rajić, Katarina AU - Čomor, Jožef J. AU - Zivanov-Stakic, D PY - 2000 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2337 AB - The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively). (C) 2000 Elsevier Science S.A. All rights reserved. T2 - Il Farmaco T1 - UV derivative spectrophotometric study of the photochemical degradation of nisoldipine VL - 55 IS - 2 SP - 128 EP - 133 DO - 10.1016/S0014-827X(00)00004-5 ER -
@article{ author = "Marinkovic, V and Agbaba, Danica and Karljiković-Rajić, Katarina and Čomor, Jožef J. and Zivanov-Stakic, D", year = "2000", abstract = "The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively). (C) 2000 Elsevier Science S.A. All rights reserved.", journal = "Il Farmaco", title = "UV derivative spectrophotometric study of the photochemical degradation of nisoldipine", volume = "55", number = "2", pages = "128-133", doi = "10.1016/S0014-827X(00)00004-5" }
Marinkovic, V., Agbaba, D., Karljiković-Rajić, K., Čomor, J. J.,& Zivanov-Stakic, D.. (2000). UV derivative spectrophotometric study of the photochemical degradation of nisoldipine. in Il Farmaco, 55(2), 128-133. https://doi.org/10.1016/S0014-827X(00)00004-5
Marinkovic V, Agbaba D, Karljiković-Rajić K, Čomor JJ, Zivanov-Stakic D. UV derivative spectrophotometric study of the photochemical degradation of nisoldipine. in Il Farmaco. 2000;55(2):128-133. doi:10.1016/S0014-827X(00)00004-5 .
Marinkovic, V, Agbaba, Danica, Karljiković-Rajić, Katarina, Čomor, Jožef J., Zivanov-Stakic, D, "UV derivative spectrophotometric study of the photochemical degradation of nisoldipine" in Il Farmaco, 55, no. 2 (2000):128-133, https://doi.org/10.1016/S0014-827X(00)00004-5 . .