Apolipoprotein E gene DNA polymorphism in Serbian population
Apstrakt
The study estimates the distribution of apoE alleles in Serbian population (622 persons) by restriction isotyping of the amplified apoE gene sequence and MADGE analysis. The E2 allele frequency estimated here (0.149) is one of the highest ever reported. A lowering in E4 frequency (0.115) compensates the increasing in E2 allele frequency. The E3 allele frequency remains comparable to Frequencies reported in other white populations. The frequency pattern of apoE alleles follows the same trend as one observed in other Caucasian European populations where the E3 allele is the most frequent (0.736). The low prevalence of E4 allele (0.114) was in agreement with underexpression of E4 in Southern Europe, compared to northern regions.
Ključne reči:
apoE / allele frequencies / Serbian population / genetic epidemiology / restriction isotypingIzvor:
Jugoslovenska Medicinska Biohemija, 1999, 18, 1, 9-15Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Stanković, Sanja AU - Glišić, Sanja AU - Alavantić, Dragan PY - 1999 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2241 AB - The study estimates the distribution of apoE alleles in Serbian population (622 persons) by restriction isotyping of the amplified apoE gene sequence and MADGE analysis. The E2 allele frequency estimated here (0.149) is one of the highest ever reported. A lowering in E4 frequency (0.115) compensates the increasing in E2 allele frequency. The E3 allele frequency remains comparable to Frequencies reported in other white populations. The frequency pattern of apoE alleles follows the same trend as one observed in other Caucasian European populations where the E3 allele is the most frequent (0.736). The low prevalence of E4 allele (0.114) was in agreement with underexpression of E4 in Southern Europe, compared to northern regions. T2 - Jugoslovenska Medicinska Biohemija T1 - Apolipoprotein E gene DNA polymorphism in Serbian population VL - 18 IS - 1 SP - 9 EP - 15 UR - https://hdl.handle.net/21.15107/rcub_vinar_2241 ER -
@article{ author = "Stanković, Sanja and Glišić, Sanja and Alavantić, Dragan", year = "1999", abstract = "The study estimates the distribution of apoE alleles in Serbian population (622 persons) by restriction isotyping of the amplified apoE gene sequence and MADGE analysis. The E2 allele frequency estimated here (0.149) is one of the highest ever reported. A lowering in E4 frequency (0.115) compensates the increasing in E2 allele frequency. The E3 allele frequency remains comparable to Frequencies reported in other white populations. The frequency pattern of apoE alleles follows the same trend as one observed in other Caucasian European populations where the E3 allele is the most frequent (0.736). The low prevalence of E4 allele (0.114) was in agreement with underexpression of E4 in Southern Europe, compared to northern regions.", journal = "Jugoslovenska Medicinska Biohemija", title = "Apolipoprotein E gene DNA polymorphism in Serbian population", volume = "18", number = "1", pages = "9-15", url = "https://hdl.handle.net/21.15107/rcub_vinar_2241" }
Stanković, S., Glišić, S.,& Alavantić, D.. (1999). Apolipoprotein E gene DNA polymorphism in Serbian population. in Jugoslovenska Medicinska Biohemija, 18(1), 9-15. https://hdl.handle.net/21.15107/rcub_vinar_2241
Stanković S, Glišić S, Alavantić D. Apolipoprotein E gene DNA polymorphism in Serbian population. in Jugoslovenska Medicinska Biohemija. 1999;18(1):9-15. https://hdl.handle.net/21.15107/rcub_vinar_2241 .
Stanković, Sanja, Glišić, Sanja, Alavantić, Dragan, "Apolipoprotein E gene DNA polymorphism in Serbian population" in Jugoslovenska Medicinska Biohemija, 18, no. 1 (1999):9-15, https://hdl.handle.net/21.15107/rcub_vinar_2241 .