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Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations
dc.creator | Marinković, Valentina D. | |
dc.creator | Milojković, Smiljana S. | |
dc.creator | Nedeljković, Jovan | |
dc.creator | Čomor, Jožef J. | |
dc.creator | Agbaba, Danica | |
dc.creator | Živanov-Stakić, Dobrila | |
dc.date.accessioned | 2018-03-01T18:22:57Z | |
dc.date.available | 2018-03-01T18:22:57Z | |
dc.date.issued | 1997 | |
dc.identifier.issn | 0731-7085 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2099 | |
dc.description.abstract | A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (ISSMN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 mu g in dosage formulations for ISSMN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of ISSMN. (C) 1997 Elsevier Science B.V. | en |
dc.relation | Ministry of Science and Technology of the Republic of Serbia | |
dc.rights | restrictedAccess | en |
dc.source | Journal of Pharmaceutical and Biomedical Analysis | en |
dc.subject | isosorbide | en |
dc.subject | isosorbide 5-mononitrate | en |
dc.subject | isosorbide diacetate | en |
dc.subject | isosorbide-2-acetate-5-nitrate | en |
dc.subject | gas chromatography mass spectrometry | en |
dc.subject | quality control | en |
dc.title | Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Милојковиц, СС; Маринковиц, ВД; Aгбаба, Д; Цомор, ЈЈ; ЗивановСтакиц, Д; Недељковић Јован; | |
dc.citation.volume | 16 | |
dc.citation.issue | 3 | |
dc.citation.spage | 425 | |
dc.citation.epage | 429 | |
dc.identifier.wos | A1997YJ69500007 | |
dc.identifier.doi | 10.1016/S0731-7085(97)00079-4 | |
dc.identifier.pmid | 9589400 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-0030732906 |
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