Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver
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1997
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Activities of superoxide dismutases MnSOD and CuZnSOD were measured in appropriate subcellular fractions prepared from livers of intact and long-term gonadectomized (GX) rats of both sexes, and of GX female and male rats injected sc with a single dose of 5 mu g estradiol benzoate (EB) or 2 mg progesterone (P). In female livers, MnSOD activity did not vary significantly during the estrous cycle, declined after gonadectomy in comparison to proestrus, and was steady in GX females treated with EB or P. The activity of CuZnSOD was lowered at proestrus and elevated after removal of the ovaries in comparison to proestrus value. EB suppressed, and P elevated CuZnSOD activity in GX females. In the liver of male rats, MnSOD was not affected by gonadectomy nor by EB and P treatments. CuZnSOD activity was reduced following orchiectomy and enhanced in GX mates following treatment with P, while EB had no effect. These results suggest that P and EB modulate the activity of CuZnSOD and do not affect M...nSOD in the rat liver. The modulatory effects are elicited by P in the males and by P and EB in the females. (C) 1997, Editrice Kurtis.
Ključne reči:
superoxide dismutase / rat / liver / estradiol / progesteroneIzvor:
Journal of Endocrinological Investigation, 1997, 20, 4, 203-206
DOI: 10.1007/BF03346903
ISSN: 0391-4097
PubMed: 9211126
WoS: A1997XB83300005
Scopus: 2-s2.0-0030809486
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VinčaTY - JOUR AU - Kasapović, Jelena AU - Pajović, Snežana B. AU - Kanazir, Dušan T. AU - Martinović, Jelena PY - 1997 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2070 AB - Activities of superoxide dismutases MnSOD and CuZnSOD were measured in appropriate subcellular fractions prepared from livers of intact and long-term gonadectomized (GX) rats of both sexes, and of GX female and male rats injected sc with a single dose of 5 mu g estradiol benzoate (EB) or 2 mg progesterone (P). In female livers, MnSOD activity did not vary significantly during the estrous cycle, declined after gonadectomy in comparison to proestrus, and was steady in GX females treated with EB or P. The activity of CuZnSOD was lowered at proestrus and elevated after removal of the ovaries in comparison to proestrus value. EB suppressed, and P elevated CuZnSOD activity in GX females. In the liver of male rats, MnSOD was not affected by gonadectomy nor by EB and P treatments. CuZnSOD activity was reduced following orchiectomy and enhanced in GX mates following treatment with P, while EB had no effect. These results suggest that P and EB modulate the activity of CuZnSOD and do not affect MnSOD in the rat liver. The modulatory effects are elicited by P in the males and by P and EB in the females. (C) 1997, Editrice Kurtis. T2 - Journal of Endocrinological Investigation T1 - Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver VL - 20 IS - 4 SP - 203 EP - 206 DO - 10.1007/BF03346903 ER -
@article{ author = "Kasapović, Jelena and Pajović, Snežana B. and Kanazir, Dušan T. and Martinović, Jelena", year = "1997", abstract = "Activities of superoxide dismutases MnSOD and CuZnSOD were measured in appropriate subcellular fractions prepared from livers of intact and long-term gonadectomized (GX) rats of both sexes, and of GX female and male rats injected sc with a single dose of 5 mu g estradiol benzoate (EB) or 2 mg progesterone (P). In female livers, MnSOD activity did not vary significantly during the estrous cycle, declined after gonadectomy in comparison to proestrus, and was steady in GX females treated with EB or P. The activity of CuZnSOD was lowered at proestrus and elevated after removal of the ovaries in comparison to proestrus value. EB suppressed, and P elevated CuZnSOD activity in GX females. In the liver of male rats, MnSOD was not affected by gonadectomy nor by EB and P treatments. CuZnSOD activity was reduced following orchiectomy and enhanced in GX mates following treatment with P, while EB had no effect. These results suggest that P and EB modulate the activity of CuZnSOD and do not affect MnSOD in the rat liver. The modulatory effects are elicited by P in the males and by P and EB in the females. (C) 1997, Editrice Kurtis.", journal = "Journal of Endocrinological Investigation", title = "Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver", volume = "20", number = "4", pages = "203-206", doi = "10.1007/BF03346903" }
Kasapović, J., Pajović, S. B., Kanazir, D. T.,& Martinović, J.. (1997). Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver. in Journal of Endocrinological Investigation, 20(4), 203-206. https://doi.org/10.1007/BF03346903
Kasapović J, Pajović SB, Kanazir DT, Martinović J. Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver. in Journal of Endocrinological Investigation. 1997;20(4):203-206. doi:10.1007/BF03346903 .
Kasapović, Jelena, Pajović, Snežana B., Kanazir, Dušan T., Martinović, Jelena, "Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver" in Journal of Endocrinological Investigation, 20, no. 4 (1997):203-206, https://doi.org/10.1007/BF03346903 . .