The effect of the preparation conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate kit solution has been examined. To extend the shelf-life of the preparation, different methods of protection were tested. Nitrogen purging stabilizes the kit for at least 6 h after labeling when the content of (99)mTc-pertechnetate raises to about 5%. However, this method is ineffective in the presence of hydrogen peroxide. The protecting ability of two chemicals was also determined. Gentisic acid gave good results. In the presence of 50 mu g of gentisic acid per mi of the kit the content of pertechnetate was 1-2% throughout the examined time interval. To eliminate the influence of hydrogen peroxide (6 mu g per ml of the kit) about 100 mu g of gentisic acid is needed. N,N-diphenyl-p-phenylenediamine (DPPD) performs some protecting effect only when used in the samples protected by nitrogen purging. However its protecting ability is lower that in the case of gentisic acid.
Извор:
Journal of Radioanalytical and Nuclear Chemistry - Letters, 1996, 214, 1, 29-39
TY - JOUR
AU - Vučina, Jurij L.
PY - 1996
UR - https://vinar.vin.bg.ac.rs/handle/123456789/2044
AB - The effect of the preparation conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate kit solution has been examined. To extend the shelf-life of the preparation, different methods of protection were tested. Nitrogen purging stabilizes the kit for at least 6 h after labeling when the content of (99)mTc-pertechnetate raises to about 5%. However, this method is ineffective in the presence of hydrogen peroxide. The protecting ability of two chemicals was also determined. Gentisic acid gave good results. In the presence of 50 mu g of gentisic acid per mi of the kit the content of pertechnetate was 1-2% throughout the examined time interval. To eliminate the influence of hydrogen peroxide (6 mu g per ml of the kit) about 100 mu g of gentisic acid is needed. N,N-diphenyl-p-phenylenediamine (DPPD) performs some protecting effect only when used in the samples protected by nitrogen purging. However its protecting ability is lower that in the case of gentisic acid.
T2 - Journal of Radioanalytical and Nuclear Chemistry - Letters
T1 - Shelf-life of Tc-99m(Sn)-pyrophosphate
VL - 214
IS - 1
SP - 29
EP - 39
DO - 10.1007/BF02165056
ER -
@article{
author = "Vučina, Jurij L.",
year = "1996",
abstract = "The effect of the preparation conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate kit solution has been examined. To extend the shelf-life of the preparation, different methods of protection were tested. Nitrogen purging stabilizes the kit for at least 6 h after labeling when the content of (99)mTc-pertechnetate raises to about 5%. However, this method is ineffective in the presence of hydrogen peroxide. The protecting ability of two chemicals was also determined. Gentisic acid gave good results. In the presence of 50 mu g of gentisic acid per mi of the kit the content of pertechnetate was 1-2% throughout the examined time interval. To eliminate the influence of hydrogen peroxide (6 mu g per ml of the kit) about 100 mu g of gentisic acid is needed. N,N-diphenyl-p-phenylenediamine (DPPD) performs some protecting effect only when used in the samples protected by nitrogen purging. However its protecting ability is lower that in the case of gentisic acid.",
journal = "Journal of Radioanalytical and Nuclear Chemistry - Letters",
title = "Shelf-life of Tc-99m(Sn)-pyrophosphate",
volume = "214",
number = "1",
pages = "29-39",
doi = "10.1007/BF02165056"
}
Vučina, J. L.. (1996). Shelf-life of Tc-99m(Sn)-pyrophosphate. in Journal of Radioanalytical and Nuclear Chemistry - Letters, 214(1), 29-39.
https://doi.org/10.1007/BF02165056
Vučina JL. Shelf-life of Tc-99m(Sn)-pyrophosphate. in Journal of Radioanalytical and Nuclear Chemistry - Letters. 1996;214(1):29-39.
doi:10.1007/BF02165056 .
Vučina, Jurij L., "Shelf-life of Tc-99m(Sn)-pyrophosphate" in Journal of Radioanalytical and Nuclear Chemistry - Letters, 214, no. 1 (1996):29-39,
https://doi.org/10.1007/BF02165056 . .
