Effect of experimental conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate
Apstrakt
The in vitro stability of Tc-99m(Sn)-PyP as a function of experimental conditions of the preparation of the kit and time elapsed after labeling has been tested. The preparation was protected by using nitrogen-purged reactant solutions and kit vials and by ascorbic acid. The samples under nitrogen are stable for 6 h when the content of Tc-99m-pertechnetate raises to 5%. The best stability was achieved by addition of 5 mu g of ascorbic acid per ml of the kit (content of Tc-99m-pertechnetate about 0.5%). To accelerate the decomposition, exogenous hydrogen peroxide was used. In this case it was found that the presence of 10 mu g of ascorbic acid inhibits the effect both of oxygen and peroxide (6 mu g H2O2/ml of the kit). Radiochemically purity of 99mTc(Sn)-PyP remains practically unchanged for 6 h (content of Tc-99m-pertechnetate about 0.5%).
Izvor:
Journal of Radioanalytical and Nuclear Chemistry - Letters, 1996, 212, 5, 333-340
DOI: 10.1007/BF02162648
ISSN: 0236-5731
WoS: A1996UM20400002
Scopus: 2-s2.0-0029879587
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Vučina, Jurij L. PY - 1996 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1985 AB - The in vitro stability of Tc-99m(Sn)-PyP as a function of experimental conditions of the preparation of the kit and time elapsed after labeling has been tested. The preparation was protected by using nitrogen-purged reactant solutions and kit vials and by ascorbic acid. The samples under nitrogen are stable for 6 h when the content of Tc-99m-pertechnetate raises to 5%. The best stability was achieved by addition of 5 mu g of ascorbic acid per ml of the kit (content of Tc-99m-pertechnetate about 0.5%). To accelerate the decomposition, exogenous hydrogen peroxide was used. In this case it was found that the presence of 10 mu g of ascorbic acid inhibits the effect both of oxygen and peroxide (6 mu g H2O2/ml of the kit). Radiochemically purity of 99mTc(Sn)-PyP remains practically unchanged for 6 h (content of Tc-99m-pertechnetate about 0.5%). T2 - Journal of Radioanalytical and Nuclear Chemistry - Letters T1 - Effect of experimental conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate VL - 212 IS - 5 SP - 333 EP - 340 DO - 10.1007/BF02162648 ER -
@article{ author = "Vučina, Jurij L.", year = "1996", abstract = "The in vitro stability of Tc-99m(Sn)-PyP as a function of experimental conditions of the preparation of the kit and time elapsed after labeling has been tested. The preparation was protected by using nitrogen-purged reactant solutions and kit vials and by ascorbic acid. The samples under nitrogen are stable for 6 h when the content of Tc-99m-pertechnetate raises to 5%. The best stability was achieved by addition of 5 mu g of ascorbic acid per ml of the kit (content of Tc-99m-pertechnetate about 0.5%). To accelerate the decomposition, exogenous hydrogen peroxide was used. In this case it was found that the presence of 10 mu g of ascorbic acid inhibits the effect both of oxygen and peroxide (6 mu g H2O2/ml of the kit). Radiochemically purity of 99mTc(Sn)-PyP remains practically unchanged for 6 h (content of Tc-99m-pertechnetate about 0.5%).", journal = "Journal of Radioanalytical and Nuclear Chemistry - Letters", title = "Effect of experimental conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate", volume = "212", number = "5", pages = "333-340", doi = "10.1007/BF02162648" }
Vučina, J. L.. (1996). Effect of experimental conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate. in Journal of Radioanalytical and Nuclear Chemistry - Letters, 212(5), 333-340. https://doi.org/10.1007/BF02162648
Vučina JL. Effect of experimental conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate. in Journal of Radioanalytical and Nuclear Chemistry - Letters. 1996;212(5):333-340. doi:10.1007/BF02162648 .
Vučina, Jurij L., "Effect of experimental conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate" in Journal of Radioanalytical and Nuclear Chemistry - Letters, 212, no. 5 (1996):333-340, https://doi.org/10.1007/BF02162648 . .