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dc.creatorSpasojević-Tišma, Vera D.
dc.creatorMatović, Milovan
dc.creatorMihaljević, Olgica B.
dc.creatorŽivančević-Simonović, Snežana T.
dc.creatorJeremic, Marija Z.
dc.creatorJakovljević, Vladimir Lj.
dc.creatorTodorović, Vera N.
dc.creatorPavlović, Ivan
dc.creatorPejić, Snežana
dc.creatorTodorović, Ana
dc.date.accessioned2018-03-01T18:08:49Z
dc.date.available2018-03-01T18:08:49Z
dc.date.issued2017
dc.identifier.issn1451-3994
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/1935
dc.description.abstractThe radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchanged after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175007/RS//
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceNuclear technology and radiation protectionen
dc.subjectoxidative stressen
dc.subjectantioxidant enzymeen
dc.subjectlipid peroxidationen
dc.subjectradiotherapyen
dc.subjectthyroid canceren
dc.titleRedox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablationen
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractМатовиц, Милован Д.; Зиванцевиц-Симоновиц, Снезана Т.; Јеремиц, Марија З.; Михаљевиц, Олгица Б.; Тодоровиц, Вера Н.; Јаковљевиц, Владимир Љ.; Спасојевиц-Тисма, Вера Д.; Павловић Иван; Пејић Снежана; Тодоровић Aна;
dc.citation.volume32
dc.citation.issue4
dc.citation.spage358
dc.citation.epage365
dc.identifier.wos000423779500007
dc.identifier.doi10.2298/NTRP1704358S
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85041130299
dc.identifier.fulltexthttps://vinar.vin.bg.ac.rs//bitstream/id/12212/1931.pdf


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