Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation

2017
Authors
Spasojević-Tišma, Vera D.Matovic, Milovan D.
Mihaljevic, Olgica B.
Zivancevic-Simonovic, Snezana T.
Jeremic, Marija Z.
Jakovljević, Vladimir Lj.
Todorović, Vera N.
Pavlović, Ivan

Pejić, Snežana

Todorović, Ana

Article
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The radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchange...d after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy.
Keywords:
oxidative stress / antioxidant enzyme / lipid peroxidation / radiotherapy / thyroid cancerSource:
Nuclear technology and radiation protection, 2017, 32, 4, 358-365Projects:
- Application of biomedical engineering for preclinical and clinical practice (RS-41007)
- Pharmacological analysis of effects of biologically active substances on isolated smooth muscles from human gastrointestinal and urogenital tract (RS-175007)
DOI: 10.2298/NTRP1704358S
ISSN: 1451-3994
WoS: 000423779500007
Scopus: 2-s2.0-85041130299
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VinčaTY - JOUR AU - Spasojević-Tišma, Vera D. AU - Matovic, Milovan D. AU - Mihaljevic, Olgica B. AU - Zivancevic-Simonovic, Snezana T. AU - Jeremic, Marija Z. AU - Jakovljević, Vladimir Lj. AU - Todorović, Vera N. AU - Pavlović, Ivan AU - Pejić, Snežana AU - Todorović, Ana PY - 2017 UR - http://vinar.vin.bg.ac.rs/handle/123456789/1935 AB - The radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchanged after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy. T2 - Nuclear technology and radiation protection T1 - Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation VL - 32 IS - 4 SP - 358 EP - 365 DO - 10.2298/NTRP1704358S ER -
@article{ author = "Spasojević-Tišma, Vera D. and Matovic, Milovan D. and Mihaljevic, Olgica B. and Zivancevic-Simonovic, Snezana T. and Jeremic, Marija Z. and Jakovljević, Vladimir Lj. and Todorović, Vera N. and Pavlović, Ivan and Pejić, Snežana and Todorović, Ana", year = "2017", url = "http://vinar.vin.bg.ac.rs/handle/123456789/1935", abstract = "The radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchanged after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy.", journal = "Nuclear technology and radiation protection", title = "Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation", volume = "32", number = "4", pages = "358-365", doi = "10.2298/NTRP1704358S" }
Spasojević-Tišma VD, Matovic MD, Mihaljevic OB, Zivancevic-Simonovic ST, Jeremic MZ, Jakovljević VL, Todorović VN, Pavlović I, Pejić S, Todorović A. Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation. Nuclear technology and radiation protection. 2017;32(4):358-365
Spasojević-Tišma, V. D., Matovic, M. D., Mihaljevic, O. B., Zivancevic-Simonovic, S. T., Jeremic, M. Z., Jakovljević, V. Lj., Todorović, V. N., Pavlović, I., Pejić, S.,& Todorović, A. (2017). Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation. Nuclear technology and radiation protection, 32(4), 358-365. https://doi.org/10.2298/NTRP1704358S
Spasojević-Tišma Vera D., Matovic Milovan D., Mihaljevic Olgica B., Zivancevic-Simonovic Snezana T., Jeremic Marija Z., Jakovljević Vladimir Lj., Todorović Vera N., Pavlović Ivan, Pejić Snežana, Todorović Ana, "Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation" 32, no. 4 (2017):358-365, https://doi.org/10.2298/NTRP1704358S .