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Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
dc.creator | Lavtar, Polona | |
dc.creator | Rudolf, Gorazd | |
dc.creator | Maver, Aleš | |
dc.creator | Hodžić, Alenka | |
dc.creator | Starčević Čizmarević, Nada | |
dc.creator | Živković, Maja | |
dc.creator | Jazbec, Sasa Sega | |
dc.creator | Klemenc-Ketiš, Zalika | |
dc.creator | Kapović, Miljenko | |
dc.creator | Dinčić, Evica | |
dc.creator | Raičević, Ranko | |
dc.creator | Sepčić, Juraj | |
dc.creator | Lovrečić, Luca | |
dc.creator | Stanković, Aleksandra | |
dc.creator | Ristić, Smiljana | |
dc.creator | Peterlin, Borut | |
dc.date.accessioned | 2018-03-01T18:06:57Z | |
dc.date.available | 2018-03-01T18:06:57Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/1913 | |
dc.description.abstract | Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.5.10(-5); CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35-2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13-1.73, P = 0.002). The results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis. | en |
dc.relation | Ministry of Science and Technology, Ljubljana, Republic of Slovenia [J3-3628] | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | PLOS One | en |
dc.title | Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Лавтар, Полона; Рудолф, Горазд; Мавер, Aлес; Ходзиц, Aленка; Цизмаревиц, Нада Старцевиц; Кетис, Залика Клеменц; Каповиц, Миљенко; Динциц, Евица; Раицевиц, Ранко; Сепциц, Јурај; Ловрециц, Луца; Ристиц, Смиљана; Петерлин, Борут; Јазбец, Саса Сега; Живковић Маја; Станковић Aлександра; | |
dc.citation.volume | 13 | |
dc.citation.issue | 1 | |
dc.citation.spage | e0190601 | |
dc.identifier.wos | 000419952400042 | |
dc.identifier.doi | 10.1371/journal.pone.0190601 | |
dc.citation.other | Article Number: e0190601 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 29324865 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85040364302 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/4873/journal.pone.0190601.pdf |
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080 - Laboratorija za radiobiologiju i molekularnu genetiku
Department of Radiobiology and Molecular Genetics