Smart hydrogels with ethylene glycol propylene glycol pendant chains
Abstract
New hydrogels based on different oligo(alkylene glycol) methacrylate (OAGMA) with inverse thermoresponse and volume phase transition temperature (VPTT) were obtained and characterised in this paper. Synthesis was performed from monomer-solvent (OAGMA-water/ethanol) mixture by simultaneous radiation-induced polymerisation and crosslinking; three different OAGMA (EG(6)MA, EG(6)PG(3)MA, and PG(5)MA) were used. The main focus was made on PEG(6)PG(3)MA hydrogel based on ethylene glycol (EG) propylene glycol (PG) pendant chains with EG (6) and PG (3) block units, since in the case of POPGMA and POEGMA homopolymers (i.e. hydrogels with pure PG and EG pendant chains) the VPTTs were observed far below and far above the human body temperature, respectively. Characterisation of the hydrogels was performed by swelling, UV-Vis, FTIR, SEM, DSC and in vitro biocompatibility (cytocompatibility and haemolytic activity) investigations. Due to the possibility to combine VPTT close to human body temperatu...re with good biocompatibility, new hydrogel based on EGPG block pendant chains showed promising potential for different biomedical applications.
Keywords:
Hydrogel / Temperature responsive / Oligo(alkylene glycol) methacrylate / VPTTSource:
Journal of Polymer Research, 2018, 25, 1Funding / projects:
- Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-172026)
DOI: 10.1007/s10965-017-1408-z
ISSN: 1022-9760; 1572-8935
WoS: 000418598600001
Scopus: 2-s2.0-85038962402
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VinčaTY - JOUR AU - Rogić Miladinović, Zorana AU - Mićić, Maja M. AU - Mraković, Ana Đ. AU - Suljovrujić, Edin H. PY - 2018 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1884 AB - New hydrogels based on different oligo(alkylene glycol) methacrylate (OAGMA) with inverse thermoresponse and volume phase transition temperature (VPTT) were obtained and characterised in this paper. Synthesis was performed from monomer-solvent (OAGMA-water/ethanol) mixture by simultaneous radiation-induced polymerisation and crosslinking; three different OAGMA (EG(6)MA, EG(6)PG(3)MA, and PG(5)MA) were used. The main focus was made on PEG(6)PG(3)MA hydrogel based on ethylene glycol (EG) propylene glycol (PG) pendant chains with EG (6) and PG (3) block units, since in the case of POPGMA and POEGMA homopolymers (i.e. hydrogels with pure PG and EG pendant chains) the VPTTs were observed far below and far above the human body temperature, respectively. Characterisation of the hydrogels was performed by swelling, UV-Vis, FTIR, SEM, DSC and in vitro biocompatibility (cytocompatibility and haemolytic activity) investigations. Due to the possibility to combine VPTT close to human body temperature with good biocompatibility, new hydrogel based on EGPG block pendant chains showed promising potential for different biomedical applications. T2 - Journal of Polymer Research T1 - Smart hydrogels with ethylene glycol propylene glycol pendant chains VL - 25 IS - 1 DO - 10.1007/s10965-017-1408-z ER -
@article{ author = "Rogić Miladinović, Zorana and Mićić, Maja M. and Mraković, Ana Đ. and Suljovrujić, Edin H.", year = "2018", abstract = "New hydrogels based on different oligo(alkylene glycol) methacrylate (OAGMA) with inverse thermoresponse and volume phase transition temperature (VPTT) were obtained and characterised in this paper. Synthesis was performed from monomer-solvent (OAGMA-water/ethanol) mixture by simultaneous radiation-induced polymerisation and crosslinking; three different OAGMA (EG(6)MA, EG(6)PG(3)MA, and PG(5)MA) were used. The main focus was made on PEG(6)PG(3)MA hydrogel based on ethylene glycol (EG) propylene glycol (PG) pendant chains with EG (6) and PG (3) block units, since in the case of POPGMA and POEGMA homopolymers (i.e. hydrogels with pure PG and EG pendant chains) the VPTTs were observed far below and far above the human body temperature, respectively. Characterisation of the hydrogels was performed by swelling, UV-Vis, FTIR, SEM, DSC and in vitro biocompatibility (cytocompatibility and haemolytic activity) investigations. Due to the possibility to combine VPTT close to human body temperature with good biocompatibility, new hydrogel based on EGPG block pendant chains showed promising potential for different biomedical applications.", journal = "Journal of Polymer Research", title = "Smart hydrogels with ethylene glycol propylene glycol pendant chains", volume = "25", number = "1", doi = "10.1007/s10965-017-1408-z" }
Rogić Miladinović, Z., Mićić, M. M., Mraković, A. Đ.,& Suljovrujić, E. H.. (2018). Smart hydrogels with ethylene glycol propylene glycol pendant chains. in Journal of Polymer Research, 25(1). https://doi.org/10.1007/s10965-017-1408-z
Rogić Miladinović Z, Mićić MM, Mraković AĐ, Suljovrujić EH. Smart hydrogels with ethylene glycol propylene glycol pendant chains. in Journal of Polymer Research. 2018;25(1). doi:10.1007/s10965-017-1408-z .
Rogić Miladinović, Zorana, Mićić, Maja M., Mraković, Ana Đ., Suljovrujić, Edin H., "Smart hydrogels with ethylene glycol propylene glycol pendant chains" in Journal of Polymer Research, 25, no. 1 (2018), https://doi.org/10.1007/s10965-017-1408-z . .