Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications
Само за регистроване кориснике
2017
Аутори
Radović, MagdalenaMirković, Marija D.
Perić, Marko R.
Janković, Drina
Vukadinović, Aleksandar
Stanković, Dragana
Bošković, Marko
Antić, Bratislav
Marković, Mirjana
Vranješ-Đurić, Sanja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity and magnetic energy at a tumor site. The coating of MNPs with phosphates made them biocompatible, increased their colloidal stability and allowed binding of the radionuclide Y-90 to the available functional groups on the surface of the MNPs. IDP and IHP have not hitherto been used for the coating of MNPs and the results of this study of the functionalized MNPs showed that the phosphate groups influenced the modification of the surface of MNPs. Characterization of the MNPs was performed using X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and laser Doppler electrophoresis. The specific power absorption values obtained for MNPs (46.95-80.76 W g(-1)) in different physiological media indicated t...heir possible application in hyperthermia treatment. Both types of coated MNPs were Y-90-labeled in a reproducible high yield ( GT 98%). In vitro studies of Y-90-MNPs in saline and human serum showed their high stability after 72 h. The biodistribution pattern of the MNPs after intravenous administration to healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-Fe3O4-IDP and Y-90-Fe3O4-IHP MNPs were predominantly found in the liver (85.21% ID and 86.22% ID), followed by the spleen (9.23% ID and 8.82% ID) and the lungs (1.53% ID and 1.53% ID). The results of this comprehensive study showed that radiolabeled biocompatible phosphate magnetic complexes hold great promise for therapeutic uses combining magnetic hyperthermia and radiotherapy.
Извор:
Journal of Materials Chemistry. B, 2017, 5, 44, 8738-8747Финансирање / пројекти:
- Магнетни и радионуклидима обележени наноструктурни материјали за примене у медицини (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45015)
DOI: 10.1039/c7tb02075a
ISSN: 2050-750X; 2050-7518
WoS: 000415354000010
Scopus: 2-s2.0-85034217321
Институција/група
VinčaTY - JOUR AU - Radović, Magdalena AU - Mirković, Marija D. AU - Perić, Marko R. AU - Janković, Drina AU - Vukadinović, Aleksandar AU - Stanković, Dragana AU - Bošković, Marko AU - Antić, Bratislav AU - Marković, Mirjana AU - Vranješ-Đurić, Sanja PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1830 AB - Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity and magnetic energy at a tumor site. The coating of MNPs with phosphates made them biocompatible, increased their colloidal stability and allowed binding of the radionuclide Y-90 to the available functional groups on the surface of the MNPs. IDP and IHP have not hitherto been used for the coating of MNPs and the results of this study of the functionalized MNPs showed that the phosphate groups influenced the modification of the surface of MNPs. Characterization of the MNPs was performed using X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and laser Doppler electrophoresis. The specific power absorption values obtained for MNPs (46.95-80.76 W g(-1)) in different physiological media indicated their possible application in hyperthermia treatment. Both types of coated MNPs were Y-90-labeled in a reproducible high yield ( GT 98%). In vitro studies of Y-90-MNPs in saline and human serum showed their high stability after 72 h. The biodistribution pattern of the MNPs after intravenous administration to healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-Fe3O4-IDP and Y-90-Fe3O4-IHP MNPs were predominantly found in the liver (85.21% ID and 86.22% ID), followed by the spleen (9.23% ID and 8.82% ID) and the lungs (1.53% ID and 1.53% ID). The results of this comprehensive study showed that radiolabeled biocompatible phosphate magnetic complexes hold great promise for therapeutic uses combining magnetic hyperthermia and radiotherapy. T2 - Journal of Materials Chemistry. B T1 - Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications VL - 5 IS - 44 SP - 8738 EP - 8747 DO - 10.1039/c7tb02075a ER -
@article{ author = "Radović, Magdalena and Mirković, Marija D. and Perić, Marko R. and Janković, Drina and Vukadinović, Aleksandar and Stanković, Dragana and Bošković, Marko and Antić, Bratislav and Marković, Mirjana and Vranješ-Đurić, Sanja", year = "2017", abstract = "Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity and magnetic energy at a tumor site. The coating of MNPs with phosphates made them biocompatible, increased their colloidal stability and allowed binding of the radionuclide Y-90 to the available functional groups on the surface of the MNPs. IDP and IHP have not hitherto been used for the coating of MNPs and the results of this study of the functionalized MNPs showed that the phosphate groups influenced the modification of the surface of MNPs. Characterization of the MNPs was performed using X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and laser Doppler electrophoresis. The specific power absorption values obtained for MNPs (46.95-80.76 W g(-1)) in different physiological media indicated their possible application in hyperthermia treatment. Both types of coated MNPs were Y-90-labeled in a reproducible high yield ( GT 98%). In vitro studies of Y-90-MNPs in saline and human serum showed their high stability after 72 h. The biodistribution pattern of the MNPs after intravenous administration to healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-Fe3O4-IDP and Y-90-Fe3O4-IHP MNPs were predominantly found in the liver (85.21% ID and 86.22% ID), followed by the spleen (9.23% ID and 8.82% ID) and the lungs (1.53% ID and 1.53% ID). The results of this comprehensive study showed that radiolabeled biocompatible phosphate magnetic complexes hold great promise for therapeutic uses combining magnetic hyperthermia and radiotherapy.", journal = "Journal of Materials Chemistry. B", title = "Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications", volume = "5", number = "44", pages = "8738-8747", doi = "10.1039/c7tb02075a" }
Radović, M., Mirković, M. D., Perić, M. R., Janković, D., Vukadinović, A., Stanković, D., Bošković, M., Antić, B., Marković, M.,& Vranješ-Đurić, S.. (2017). Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications. in Journal of Materials Chemistry. B, 5(44), 8738-8747. https://doi.org/10.1039/c7tb02075a
Radović M, Mirković MD, Perić MR, Janković D, Vukadinović A, Stanković D, Bošković M, Antić B, Marković M, Vranješ-Đurić S. Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications. in Journal of Materials Chemistry. B. 2017;5(44):8738-8747. doi:10.1039/c7tb02075a .
Radović, Magdalena, Mirković, Marija D., Perić, Marko R., Janković, Drina, Vukadinović, Aleksandar, Stanković, Dragana, Bošković, Marko, Antić, Bratislav, Marković, Mirjana, Vranješ-Đurić, Sanja, "Design and preparation of Y-90-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications" in Journal of Materials Chemistry. B, 5, no. 44 (2017):8738-8747, https://doi.org/10.1039/c7tb02075a . .