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dc.creatorJovanović, Aleksandra
dc.creatorObradović, Milan M.
dc.creatorSudar, Emina
dc.creatorStewart, Alan J.
dc.creatorPitt, Samantha J.
dc.creatorAlavantić, Dragan
dc.creatorAleksić, Ema
dc.creatorIsenović, Esma R.
dc.date.accessioned2018-03-01T17:58:17Z
dc.date.available2018-03-01T17:58:17Z
dc.date.issued2017
dc.identifier.issn0300-8177 (print)
dc.identifier.issn1573-4919 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1812
dc.description.abstractThe aim of this study was to investigate whether the presence of endogenous estradiol alters the effects of a high-fat (HF) diet on activity/expression of the cardiac Na+/K+-ATPase, via PI3K/IRS and RhoA/ROCK signalling cascades in female rats. For this study, female Wistar rats (8 weeks old, 150-200 g) were fed a standard diet or a HF diet (balanced diet for laboratory rats enriched with 42% fat) for 10 weeks. The results show that rats fed a HF diet exhibited a decrease in phosphorylation of the alpha(1) subunit of Na+/K+-ATPase by 30% (p LT 0.05), expression of total alpha(1) subunit of Na+/K+-ATPase by 31% (p LT 0.05), and association of IRS1 with p85 subunit of PI3K by 42% (p LT 0.05), while the levels of cardiac RhoA and ROCK2 were significantly increased by 84% (p LT 0.01) and 62% (p LT 0.05), respectively. Our results suggest that a HF diet alters cardiac Na+/K+-ATPase expression via molecular mechanisms involving RhoA/ROCK and IRS-1/PI3K signalling in female rats.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41028/RS//
dc.rightsrestrictedAccessen
dc.sourceMolecular and Cellular Biochemistryen
dc.subjectHigh-fat dieten
dc.subjectEstradiolen
dc.subjectNa+/K+-ATPaseen
dc.subjectObesityen
dc.subjectRhoA/ROCK signallingen
dc.subjectFemaleen
dc.titleChanges in cardiac Na+/K+-ATPase expression and activity in female rats fed a high-fat dieten
dc.typearticleen
dcterms.abstractПитт, Самантха Ј.; Јовановић Aлександра; Стеwарт, Aлан Ј.; Обрадовић Милан; Aлексиц, Ема; Судар Емина; Aлавантић Драган; Исеновић Есма;
dc.citation.volume436
dc.citation.issue1-2
dc.citation.spage49
dc.citation.epage58
dc.identifier.wos000414696600006
dc.identifier.doi10.1007/s11010-017-3077-y
dc.identifier.pmid28567564
dc.identifier.scopus2-s2.0-85020098496


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