Hippocampal BDNF in physiological conditions and social isolation
Abstract
Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. Given that depression in humans has been linked with social stress, the chronic social stress paradigms for modeling psychiatric disorders in animals have thus been developed. Chronic social isolation in animal models generally causes changes in hypothalamic-pituitary-adrenal axis functioning, associated with anxiety-and depressive-like behaviors. Also, this chronic stress causes downregulation of BDNF protein and mRNA in the hippocampus, a stress-sensitive brain region closely related to the pathophysiology of depression. In this review, we discuss the current knowledge regarding the structure, function, intracellular signaling, inter-individual differences and epigenetic regulation of BDNF in both physiological conditions and depression and changes in corticosterone levels, as a mar...ker of stress response. Since BDNF levels are age dependent in humans and rodents, this review will also highlight the effects of adolescent and adult chronic social isolation models of both genders on the BDNF expression.
Keywords:
BDNF / behavior / corticosterone / depression / social stressSource:
Reviews in the Neurosciences, 2017, 28, 6, 675-692Funding / projects:
- Antioxidative defense, differentiation and regeneration potential of tissue specific mesenchymal stem cells during ageing (RS-175061)
- Effects of metabolic and nonmetabolic stressors on the expression and action of neuroendocrine regulators of energy homeostasis (RS-173023)
DOI: 10.1515/revneuro-2016-0072
ISSN: 0334-1763; 1607-8470
PubMed: 28593903
WoS: 000406938300006
Scopus: 2-s2.0-85027018922
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VinčaTY - JOUR AU - Zaletel, Ivan AU - Filipović, Dragana AU - Puškaš, Nela PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1664 AB - Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. Given that depression in humans has been linked with social stress, the chronic social stress paradigms for modeling psychiatric disorders in animals have thus been developed. Chronic social isolation in animal models generally causes changes in hypothalamic-pituitary-adrenal axis functioning, associated with anxiety-and depressive-like behaviors. Also, this chronic stress causes downregulation of BDNF protein and mRNA in the hippocampus, a stress-sensitive brain region closely related to the pathophysiology of depression. In this review, we discuss the current knowledge regarding the structure, function, intracellular signaling, inter-individual differences and epigenetic regulation of BDNF in both physiological conditions and depression and changes in corticosterone levels, as a marker of stress response. Since BDNF levels are age dependent in humans and rodents, this review will also highlight the effects of adolescent and adult chronic social isolation models of both genders on the BDNF expression. T2 - Reviews in the Neurosciences T1 - Hippocampal BDNF in physiological conditions and social isolation VL - 28 IS - 6 SP - 675 EP - 692 DO - 10.1515/revneuro-2016-0072 ER -
@article{ author = "Zaletel, Ivan and Filipović, Dragana and Puškaš, Nela", year = "2017", abstract = "Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. Given that depression in humans has been linked with social stress, the chronic social stress paradigms for modeling psychiatric disorders in animals have thus been developed. Chronic social isolation in animal models generally causes changes in hypothalamic-pituitary-adrenal axis functioning, associated with anxiety-and depressive-like behaviors. Also, this chronic stress causes downregulation of BDNF protein and mRNA in the hippocampus, a stress-sensitive brain region closely related to the pathophysiology of depression. In this review, we discuss the current knowledge regarding the structure, function, intracellular signaling, inter-individual differences and epigenetic regulation of BDNF in both physiological conditions and depression and changes in corticosterone levels, as a marker of stress response. Since BDNF levels are age dependent in humans and rodents, this review will also highlight the effects of adolescent and adult chronic social isolation models of both genders on the BDNF expression.", journal = "Reviews in the Neurosciences", title = "Hippocampal BDNF in physiological conditions and social isolation", volume = "28", number = "6", pages = "675-692", doi = "10.1515/revneuro-2016-0072" }
Zaletel, I., Filipović, D.,& Puškaš, N.. (2017). Hippocampal BDNF in physiological conditions and social isolation. in Reviews in the Neurosciences, 28(6), 675-692. https://doi.org/10.1515/revneuro-2016-0072
Zaletel I, Filipović D, Puškaš N. Hippocampal BDNF in physiological conditions and social isolation. in Reviews in the Neurosciences. 2017;28(6):675-692. doi:10.1515/revneuro-2016-0072 .
Zaletel, Ivan, Filipović, Dragana, Puškaš, Nela, "Hippocampal BDNF in physiological conditions and social isolation" in Reviews in the Neurosciences, 28, no. 6 (2017):675-692, https://doi.org/10.1515/revneuro-2016-0072 . .