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Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS)
dc.creator | Herrick, Ariane L. | |
dc.creator | Pan, Xiaoyan | |
dc.creator | Peytrignet, Sebastien | |
dc.creator | Lunt, Mark | |
dc.creator | Hesselstrand, Roger | |
dc.creator | Mouthon, Luc | |
dc.creator | Silman, Alan | |
dc.creator | Brown, Edith | |
dc.creator | Czirjak, Laszlo | |
dc.creator | Distler, Joerg H. W. | |
dc.creator | Distler, Oliver | |
dc.creator | Fligelstone, Kim | |
dc.creator | Gregory, William J. | |
dc.creator | Ochiel, Rachel | |
dc.creator | Vonk, Madelon | |
dc.creator | Ancuta, Codrina | |
dc.creator | Ong, Voon H. | |
dc.creator | Farge, Dominique | |
dc.creator | Hudson, Marie | |
dc.creator | Matucci-Cerinic, Marco | |
dc.creator | Balbir-Gurman, Alexandra | |
dc.creator | Midtvedt, Oyvind | |
dc.creator | Jordan, Alison C. | |
dc.creator | Jobanputra, Paresh | |
dc.creator | Stevens, Wendy | |
dc.creator | Moinzadeh, Pia | |
dc.creator | Hall, Frances C. | |
dc.creator | Agard, Christian | |
dc.creator | Anderson, Marina E. | |
dc.creator | Diot, Elisabeth | |
dc.creator | Madhok, Rajan | |
dc.creator | Akil, Mohammed | |
dc.creator | Buch, Maya H. | |
dc.creator | Chung, Lorinda | |
dc.creator | Damjanov, Nemanja | |
dc.creator | Gunawardena, Harsha | |
dc.creator | Lanyon, Peter | |
dc.creator | Ahmad, Yasmeen | |
dc.creator | Chakravarty, Kuntal | |
dc.creator | Jacobsen, Soren | |
dc.creator | MacGregor, Alexander J. | |
dc.creator | McHugh, Neil | |
dc.creator | Mueller-Ladner, Ulf | |
dc.creator | Riemekasten, Gabriela | |
dc.creator | Becker, Michael | |
dc.creator | Roddy, Janet | |
dc.creator | Carreira, Patricia E. | |
dc.creator | Fauchais, Anne Laure | |
dc.creator | Hachulla, Eric | |
dc.creator | Hamilton, Jennifer | |
dc.creator | Inanc, Murat | |
dc.creator | McLaren, John S. | |
dc.creator | van Laar, Jacob M. | |
dc.creator | Pathare, Sanjay | |
dc.creator | Proudman, Susannah | |
dc.creator | Rudin, Anna | |
dc.creator | Sahhar, Joanne | |
dc.creator | Coppere, Brigitte | |
dc.creator | Serratrice, Christine | |
dc.creator | Sheeran, Tom | |
dc.creator | Veale, Douglas J. | |
dc.creator | Grange, Claire | |
dc.creator | Trad, Georges-Selim | |
dc.creator | Denton, Christopher P. | |
dc.date.accessioned | 2018-03-01T17:39:39Z | |
dc.date.available | 2018-03-01T17:39:39Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0003-4967 | |
dc.identifier.issn | 1468-2060 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/1599 | |
dc.description.abstract | Objectives The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment approaches. Methods This was a prospective, observational cohort study of early dcSSc (within three years of onset of skin thickening). Clinicians selected one of four protocols for each patient: methotrexate, mycophenolate mofetil (MMF), cyclophosphamide or no immunosuppressant. Patients were assessed three-monthly for up to 24 months. The primary outcome was the change in modified Rodnan skin score (mRSS). Confounding by indication at baseline was accounted for using inverse probability of treatment (IPT) weights. As a secondary outcome, an IPT-weighted Cox model was used to test for differences in survival. Results Of 326 patients recruited from 50 centres, 65 were prescribed methotrexate, 118 MMF, 87 cyclophosphamide and 56 no immunosuppressant. 276 (84.7%) patients completed 12 and 234 (71.7%) 24 months follow-up (or reached last visit date). There were statistically significant reductions in mRSS at 12 months in all groups: -4.0 (-5.2 to -2.7) units for methotrexate, -4.1 (-5.3 to -2.9) for MMF, -3.3 (-4.9 to -1.7) for cyclophosphamide and -2.2 (-4.0 to -0.3) for no immunosuppressant (p value for between-group differences=0.346). There were no statistically significant differences in survival between protocols before (p=0.389) or after weighting (p=0.440), but survival was poorest in the no immunosuppressant group (84.0%) at 24 months. Conclusions These findings may support using immunosuppressants for early dcSSc but suggest that overall benefit is modest over 12 months and that better treatments are needed. | en |
dc.relation | European League Against Rheumatism (EULAR) Orphan Disease Programme, Scleroderma and Raynauds UK | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Annals of the Rheumatic Diseases | en |
dc.title | Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS) | en |
dc.type | article | en |
dc.rights.license | BY-NC | |
dcterms.abstract | Aкил, Мохаммед; Царреира, Патрициа Е.; Стевенс, Wендy; Лунт, Марк; Серратрице, Цхристине; Пан, Xиаоyан; Халл, Францес Ц.; Грегорy, Wиллиам Ј.; Матуцци-Цериниц, Марцо; Јобанпутра, Паресх; Цхунг, Лоринда; Ланyон, Петер; МацГрегор, Aлеxандер Ј.; Гранге, Цлаире; ван Лаар, Јацоб М.; Јордан, Aлисон Ц.; Моутхон, Луц; Оцхиел, Рацхел; Дистлер, Оливер; Худсон, Марие; Фарге, Доминиqуе; Јацобсен, Сорен; Буцх, Маyа Х.; Силман, Aлан; Онг, Воон Х.; Дамјанов, Немања; Мидтведт, Оyвинд; Цзирјак, Ласзло; Хамилтон, Јеннифер; Флигелстоне, Ким; Aндерсон, Марина Е.; Aнцута, Цодрина; Моинзадех, Пиа; Диот, Елисабетх; Риемекастен, Габриела; Муеллер-Ладнер, Улф; Мадхок, Рајан; Дистлер, Јоерг Х. W.; Броwн, Едитх; МцХугх, Неил; Вонк, Маделон; Балбир-Гурман, Aлеxандра; Цхакравартy, Кунтал; Aгард, Цхристиан; Aхмад, Yасмеен; Гунаwардена, Харсха; МцЛарен, Јохн С.; Инанц, Мурат; Саххар, Јоанне; Проудман, Сусаннах; Патхаре, Сањаy; Трад, Георгес-Селим; Схееран, Том; Дентон, Цхристопхер П.; Бецкер, Мицхаел; Веале, Доуглас Ј.; Цоппере, Бригитте; Рудин, Aнна; Хесселстранд, Рогер; Роддy, Јанет; Хацхулла, Ериц; Херрицк, Aриане Л.; Пеyтригнет, Себастиен; Фауцхаис, Aнне Лауре; | |
dc.citation.volume | 76 | |
dc.citation.issue | 7 | |
dc.citation.spage | 1207 | |
dc.citation.epage | 1218 | |
dc.identifier.wos | 000403074400014 | |
dc.identifier.doi | 10.1136/annrheumdis-2016-210503 | |
dc.citation.rank | aM21 | |
dc.identifier.pmid | 28188239 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85020703821 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/11956/1595.pdf |