A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of s...imultaneous determination.
TY - JOUR
AU - Petković, Branka B.
AU - Kuzmanović, D.
AU - Dimitrijević, T.
AU - Krstić, Milena P.
AU - Stanković, Dalibor M.
PY - 2017
UR - https://vinar.vin.bg.ac.rs/handle/123456789/1596
AB - A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.
T2 - International Journal of Electrochemical Science
T1 - Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination
VL - 12
IS - 5
SP - 3709
EP - 3720
DO - 10.20964/2017.05.34
ER -
@article{
author = "Petković, Branka B. and Kuzmanović, D. and Dimitrijević, T. and Krstić, Milena P. and Stanković, Dalibor M.",
year = "2017",
abstract = "A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.",
journal = "International Journal of Electrochemical Science",
title = "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination",
volume = "12",
number = "5",
pages = "3709-3720",
doi = "10.20964/2017.05.34"
}
Petković, B. B., Kuzmanović, D., Dimitrijević, T., Krstić, M. P.,& Stanković, D. M.. (2017). Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science, 12(5), 3709-3720.
https://doi.org/10.20964/2017.05.34
Petković BB, Kuzmanović D, Dimitrijević T, Krstić MP, Stanković DM. Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science. 2017;12(5):3709-3720.
doi:10.20964/2017.05.34 .
Petković, Branka B., Kuzmanović, D., Dimitrijević, T., Krstić, Milena P., Stanković, Dalibor M., "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination" in International Journal of Electrochemical Science, 12, no. 5 (2017):3709-3720,
https://doi.org/10.20964/2017.05.34 . .
