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dc.creatorStanisavljević, Andrijana
dc.creatorPerić, Ivana
dc.creatorPantelić, Marija
dc.creatorFilipović, Dragana
dc.date.accessioned2018-03-01T17:39:03Z
dc.date.available2018-03-01T17:39:03Z
dc.date.issued2017
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/1592
dc.description.abstractOlanzapine, an antipsychotic drug, is used to treat depressive disorder, but its effects on the liver, the main site of drug metabolism, still remain elusive. We studied the effects of 3 weeks of olanzapine treatment (7.5 mg/kg per day) on the malondialdehyde (MDA) and protein carbonyl (PCO) contents, protein expression of copper/zinc superoxide dismutase (CuZnSOD), and activity of total superoxide dismutase (SOD), as well as catalase (CAT) protein expression and activity levels in the liver cytosol of rats exposed to 6 weeks of chronic social isolation (CSIS), which causes depressive- and anxiety-like behaviors. Increased cytosolic MDA in CSIS rats (vehicle-or olanzapine-treated) indicated hepatic oxidative stress. Increase in PCO and CAT activity associated with unchanged total SOD activity following CSIS also confirm the presence of oxidative stress. Chronic olanzapine treatment in CSIS prevented increase in PCO without an effect on MDA content. Increased SOD activity in olanzapine-treated (controls and CSIS) groups compared with corresponding vehicle-treated groups and decreased CAT activity in olanzapine-treated CSIS rats compared with vehicle-treated CSIS group was found. The data suggest that chronic olanzapine treatment has a protective effect on hepatic protein oxidation and improves antioxidant defense. The beneficial effects of olanzapine may be due to its free radical scavenging properties and antioxidant activity.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.rightsrestrictedAccessen
dc.sourceCanadian Journal of Physiology and Pharmacologyen
dc.subjectsocial isolationen
dc.subjectolanzapineen
dc.subjectliveren
dc.subjectoxidative stressen
dc.subjectantioxidative enzymesen
dc.titleOlanzapine alleviates oxidative stress in the liver of socially isolated ratsen
dc.typearticleen
dcterms.abstractСтанисављевиц, Aндријана; Перић Ивана; Пантелић Марија; Филиповић Драгана;
dc.citation.volume95
dc.citation.issue6
dc.citation.spage634
dc.citation.epage640
dc.identifier.wos000402318700002
dc.identifier.doi10.1139/cjpp-2016-0598
dc.citation.rankM22
dc.identifier.pmid28177683
dc.identifier.scopus2-s2.0-85020120179


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