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dc.creatorBaroud, Afya A.
dc.creatorMihajlović-Lalić, Ljiljana E.
dc.creatorStanković, Dalibor M.
dc.creatorKajzerberger, Marijana
dc.creatorVan Hecke, Kristof
dc.creatorGrguric-Sipka, Sanja
dc.creatorSavic, Aleksandar
dc.date.accessioned2018-03-01T17:37:06Z
dc.date.available2018-03-01T17:37:06Z
dc.date.issued2017
dc.identifier.issn0352-5139
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1569
dc.description.abstractA new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were GT 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationHercules Foundation [AUGE/11/029], Research Foundation - Flanders (FWO) [1.5.216.15N], Magbiovin project (FP7-ERAChairs-Pilot Call) [621375]
dc.rightsopenAccessen
dc.sourceJournal of the Serbian Chemical Societyen
dc.subjectmetal complexen
dc.subjectcharacterizationen
dc.subjectX-rayen
dc.subjectredox propertiesen
dc.subjectbiological studyen
dc.titleNew ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicityen
dc.typearticleen
dcterms.abstractСавиц, Aлександар; Станковић Далибор; Михајловиц-Лалиц, Љиљана Е.; Бароуд, Aфyа A.; Кајзербергер, Маријана; Ван Хецке, Кристоф; Гргуриц-Сипка, Сања;
dc.citation.volume82
dc.citation.issue3
dc.citation.spage267
dc.citation.epage275
dc.identifier.wos000401126100003
dc.identifier.doi10.2298/JSC170109025B
dc.citation.rankM23
dc.identifier.scopus2-s2.0-85018254497
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/11932/1565.pdf


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