Antioxidant status and sex hormones in women with complex endometrial hyperplasia
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Аутори
Pejić, Snežana![](/themes/MirageVinar/images/orcid.png)
Todorović, Ana
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Stojiljković, Vesna
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Pavlović, Ivan
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Gavrilović, Ljubica
![](/themes/MirageVinar/images/orcid.png)
Popović, Nataša M.
![](/themes/MirageVinar/images/orcid.png)
Pajović, Snežana B.
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Чланак у часопису (Објављена верзија)
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Приказ свих података о документуАпстракт
Endometrial tissue is under a strong influence of sex hormones. These hormones are considered as developmental factors of endometrial hyperplasia and endometrial cancer. We examined the influence of gonadotropins (follicle-stimulating and luteinizing hormone) and sex hormones (estradiol, progesterone) on oxidant/antioxidant parameters in blood and endometrial tissue of women with complex endometrial hyperplasia. In blood, superoxide dismutase activity was significantly higher in luteal phase and postmenopause compared to the follicular phase. A significant phase-related difference of glutathione peroxidase and glutathione reductase activity was recorded in the endometrium. Both enzymes had lower activity in luteal phase and postmenopause compared to the follicular phase. The linear regression analysis of individual hormonal variables against antioxidant parameters showed negative correlation between glutathione peroxidase activity and gonadotropin concentrations in the endometrium. The... regression of hyperplastic to normal endometrium is the purpose of conservative treatment based on administration of progestogens or gonadotropin-releasing hormone analogues. Our findings indicate that gonadotropins influence the antioxidant enzymes activity in women with complex endometrial hyperplasia, which may affect disease development. Further studies are needed to clarify the molecular basis of hormone action on antioxidant system that may potentially initiate a development of treatments based onredox-dependentmechanism.
Кључне речи:
Antioxidant enzymes / gonadotropins / estradiol / progesterone / hyperplasia complexИзвор:
Cellular and Molecular Biology, 2016, 62, 11, 51-56Финансирање / пројекти:
- Ћелијске и молекулске основе малигних и кардиоваскуларних обољења-клиничке импликације (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Акутни коронарни синдром: истраживање вулнерабилности (плака, крви и миокарда), оптимално лечење и одређивање прогностичких фактора (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41022)
DOI: 10.14715/cmb/2016.62.11.9
ISSN: 0145-5680; 1165-158X
PubMed: 27755952
WoS: 000396120300009
Scopus: 2-s2.0-85012009610
Колекције
Институција/група
VinčaTY - JOUR AU - Pejić, Snežana AU - Todorović, Ana AU - Stojiljković, Vesna AU - Pavlović, Ivan AU - Gavrilović, Ljubica AU - Popović, Nataša M. AU - Pajović, Snežana B. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1455 AB - Endometrial tissue is under a strong influence of sex hormones. These hormones are considered as developmental factors of endometrial hyperplasia and endometrial cancer. We examined the influence of gonadotropins (follicle-stimulating and luteinizing hormone) and sex hormones (estradiol, progesterone) on oxidant/antioxidant parameters in blood and endometrial tissue of women with complex endometrial hyperplasia. In blood, superoxide dismutase activity was significantly higher in luteal phase and postmenopause compared to the follicular phase. A significant phase-related difference of glutathione peroxidase and glutathione reductase activity was recorded in the endometrium. Both enzymes had lower activity in luteal phase and postmenopause compared to the follicular phase. The linear regression analysis of individual hormonal variables against antioxidant parameters showed negative correlation between glutathione peroxidase activity and gonadotropin concentrations in the endometrium. The regression of hyperplastic to normal endometrium is the purpose of conservative treatment based on administration of progestogens or gonadotropin-releasing hormone analogues. Our findings indicate that gonadotropins influence the antioxidant enzymes activity in women with complex endometrial hyperplasia, which may affect disease development. Further studies are needed to clarify the molecular basis of hormone action on antioxidant system that may potentially initiate a development of treatments based onredox-dependentmechanism. T2 - Cellular and Molecular Biology T1 - Antioxidant status and sex hormones in women with complex endometrial hyperplasia VL - 62 IS - 11 SP - 51 EP - 56 DO - 10.14715/cmb/2016.62.11.9 ER -
@article{ author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Pavlović, Ivan and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.", year = "2016", abstract = "Endometrial tissue is under a strong influence of sex hormones. These hormones are considered as developmental factors of endometrial hyperplasia and endometrial cancer. We examined the influence of gonadotropins (follicle-stimulating and luteinizing hormone) and sex hormones (estradiol, progesterone) on oxidant/antioxidant parameters in blood and endometrial tissue of women with complex endometrial hyperplasia. In blood, superoxide dismutase activity was significantly higher in luteal phase and postmenopause compared to the follicular phase. A significant phase-related difference of glutathione peroxidase and glutathione reductase activity was recorded in the endometrium. Both enzymes had lower activity in luteal phase and postmenopause compared to the follicular phase. The linear regression analysis of individual hormonal variables against antioxidant parameters showed negative correlation between glutathione peroxidase activity and gonadotropin concentrations in the endometrium. The regression of hyperplastic to normal endometrium is the purpose of conservative treatment based on administration of progestogens or gonadotropin-releasing hormone analogues. Our findings indicate that gonadotropins influence the antioxidant enzymes activity in women with complex endometrial hyperplasia, which may affect disease development. Further studies are needed to clarify the molecular basis of hormone action on antioxidant system that may potentially initiate a development of treatments based onredox-dependentmechanism.", journal = "Cellular and Molecular Biology", title = "Antioxidant status and sex hormones in women with complex endometrial hyperplasia", volume = "62", number = "11", pages = "51-56", doi = "10.14715/cmb/2016.62.11.9" }
Pejić, S., Todorović, A., Stojiljković, V., Pavlović, I., Gavrilović, L., Popović, N. M.,& Pajović, S. B.. (2016). Antioxidant status and sex hormones in women with complex endometrial hyperplasia. in Cellular and Molecular Biology, 62(11), 51-56. https://doi.org/10.14715/cmb/2016.62.11.9
Pejić S, Todorović A, Stojiljković V, Pavlović I, Gavrilović L, Popović NM, Pajović SB. Antioxidant status and sex hormones in women with complex endometrial hyperplasia. in Cellular and Molecular Biology. 2016;62(11):51-56. doi:10.14715/cmb/2016.62.11.9 .
Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Pavlović, Ivan, Gavrilović, Ljubica, Popović, Nataša M., Pajović, Snežana B., "Antioxidant status and sex hormones in women with complex endometrial hyperplasia" in Cellular and Molecular Biology, 62, no. 11 (2016):51-56, https://doi.org/10.14715/cmb/2016.62.11.9 . .