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Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes
dc.creator | Petrović, Voin | |
dc.creator | Petrović, Sandra | |
dc.creator | Joksić, Gordana | |
dc.creator | Savić, Jasmina | |
dc.creator | Čolović, Mirjana B. | |
dc.creator | Cinellu, Maria Agostina | |
dc.creator | Massai, Lara | |
dc.creator | Messori, Luigi | |
dc.creator | Vasić, Vesna M. | |
dc.date.accessioned | 2018-03-01T15:29:03Z | |
dc.date.available | 2018-03-01T15:29:03Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.issn | 1873-3344 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/140 | |
dc.description.abstract | Na+/K+-ATPase is in charge of maintaining the ionic and osmotic intracellular balance by using ATP as an energy source to drive excess Na+ ions out of the cell in exchange for K+ ions. We explored whether three representative cytotoxic gold(III) compounds might interfere with Na+/K+-ATPase and cause its inhibition at pharmacologically relevant concentrations. The tested complexes were [Au(bipy)(OH)(2)][PF6] (bipy = 2,2-bipyridine), [Au (py(dmb)-H)(CH3COO)(2)] (py(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-pyridine), and [Au(bipy(dmb)-H)(OH)][PF6] (bipy(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-2,2-bipyridine). We found that all of them caused a pronounced and similar inhibition of Na+/K+-ATPase activity. Inhibition was found to be non-competitive and reversible. Remarkably, treatment with cysteine resulted in reversal or prevention of Na+/K+-ATPase inhibition. It is very likely that the described effects may contribute to the overall cytotoxic profile of these gold complexes. (C) 2014 Elsevier Inc. All rights reserved. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172023/RS// | |
dc.relation | AIRC [IG-12085], Beneficentia Stiftung Vaduz | |
dc.rights | restrictedAccess | en |
dc.source | Journal of Inorganic Biochemistry | en |
dc.subject | Sodium pump | en |
dc.subject | Gold(III) complexes | en |
dc.subject | Human blood cells | en |
dc.subject | Inhibition | en |
dc.subject | Cytotoxicity | en |
dc.title | Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes | en |
dc.type | article | en |
dcterms.abstract | Чоловић Мирјана; Јоксић Гордана; Васић Весна М; Савић Јасмина; Цинеллу, Мариа Aгостина; Массаи, Лара; Мессори, Луиги; Петровиц, Воин; Петровић, Сандра; | |
dc.citation.volume | 140 | |
dc.citation.spage | 228 | |
dc.citation.epage | 235 | |
dc.identifier.wos | 000342608900028 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2014.07.015 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 25173578 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-84906965293 |
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