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dc.creatorPetrovic, Voin
dc.creatorPetrović, Sandra
dc.creatorJoksić, Gordana
dc.creatorSavić, Jasmina
dc.creatorČolović, Mirjana B.
dc.creatorCinellu, Maria Agostina
dc.creatorMassai, Lara
dc.creatorMessori, Luigi
dc.creatorVasić, Vesna M.
dc.date.accessioned2018-03-01T15:29:03Z
dc.date.available2018-03-01T15:29:03Z
dc.date.issued2014
dc.identifier.issn0162-0134 (print)
dc.identifier.issn1873-3344 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/140
dc.description.abstractNa+/K+-ATPase is in charge of maintaining the ionic and osmotic intracellular balance by using ATP as an energy source to drive excess Na+ ions out of the cell in exchange for K+ ions. We explored whether three representative cytotoxic gold(III) compounds might interfere with Na+/K+-ATPase and cause its inhibition at pharmacologically relevant concentrations. The tested complexes were [Au(bipy)(OH)(2)][PF6] (bipy = 2,2-bipyridine), [Au (py(dmb)-H)(CH3COO)(2)] (py(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-pyridine), and [Au(bipy(dmb)-H)(OH)][PF6] (bipy(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-2,2-bipyridine). We found that all of them caused a pronounced and similar inhibition of Na+/K+-ATPase activity. Inhibition was found to be non-competitive and reversible. Remarkably, treatment with cysteine resulted in reversal or prevention of Na+/K+-ATPase inhibition. It is very likely that the described effects may contribute to the overall cytotoxic profile of these gold complexes. (C) 2014 Elsevier Inc. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172023/RS//
dc.relationAIRC [IG-12085], Beneficentia Stiftung Vaduz
dc.rightsrestrictedAccessen
dc.sourceJournal of Inorganic Biochemistryen
dc.subjectSodium pumpen
dc.subjectGold(III) complexesen
dc.subjectHuman blood cellsen
dc.subjectInhibitionen
dc.subjectCytotoxicityen
dc.titleInhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexesen
dc.typearticleen
dcterms.abstractЧоловић Мирјана; Јоксић Гордана; Васић Весна М; Савић Јасмина; Цинеллу, Мариа Aгостина; Массаи, Лара; Мессори, Луиги; Петровиц, Воин; Петровић, Сандра;
dc.citation.volume140
dc.citation.spage228
dc.citation.epage235
dc.identifier.wos000342608900028
dc.identifier.doi10.1016/j.jinorgbio.2014.07.015
dc.citation.rankM21
dc.identifier.pmid25173578
dc.identifier.scopus2-s2.0-84906965293


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