Even though protons show several benefits for the therapy of ocular tumors, the application of a single RBE value in eye treatment planning is still questionable and requires further investigation. In this work, the effects of protons were experimentally measured on 92.1, a specific uveal melanoma cell line. The chosen irradiation position was the middle of the 62 MeV therapeutic Spread-Out Bragg Peak. The normal, ARPE-19 retinal cells were also used to assess the behaviour of healthy tissue exposed to irradiation. Cells were irradiated with single doses ranging from 1 to 6 Gy, and the clonogenic assay was adopted to evaluate cell survival after irradiation. The radiobiological results suggest that proton irradiation can cause significant lethal damages in both normal and cancerous cells. The obtained experimental data from biological models will serve for comparisons with Monte Carlo simulations and LEM II calculations.
TY - JOUR
AU - Keta, Otilija
AU - Petković, Vladana
AU - Petringa, G.
AU - Cirrone, G.A.P.
AU - Cammarata, F.
AU - Minafra, L.
AU - Cuttone, G.
AU - Petrović, Ivan M.
AU - Ristić-Fira, Aleksandra
PY - 2020
UR - https://vinar.vin.bg.ac.rs/handle/123456789/13495
AB - Even though protons show several benefits for the therapy of ocular tumors, the application of a single RBE value in eye treatment planning is still questionable and requires further investigation. In this work, the effects of protons were experimentally measured on 92.1, a specific uveal melanoma cell line. The chosen irradiation position was the middle of the 62 MeV therapeutic Spread-Out Bragg Peak. The normal, ARPE-19 retinal cells were also used to assess the behaviour of healthy tissue exposed to irradiation. Cells were irradiated with single doses ranging from 1 to 6 Gy, and the clonogenic assay was adopted to evaluate cell survival after irradiation. The radiobiological results suggest that proton irradiation can cause significant lethal damages in both normal and cancerous cells. The obtained experimental data from biological models will serve for comparisons with Monte Carlo simulations and LEM II calculations.
T2 - INFN-LNS Activity Report 2020
T1 - Radiosensitivity of uveal melanoma cells to photons and protons
SP - 131
EP - 132
UR - https://hdl.handle.net/21.15107/rcub_vinar_13495
ER -
@article{
author = "Keta, Otilija and Petković, Vladana and Petringa, G. and Cirrone, G.A.P. and Cammarata, F. and Minafra, L. and Cuttone, G. and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2020",
abstract = "Even though protons show several benefits for the therapy of ocular tumors, the application of a single RBE value in eye treatment planning is still questionable and requires further investigation. In this work, the effects of protons were experimentally measured on 92.1, a specific uveal melanoma cell line. The chosen irradiation position was the middle of the 62 MeV therapeutic Spread-Out Bragg Peak. The normal, ARPE-19 retinal cells were also used to assess the behaviour of healthy tissue exposed to irradiation. Cells were irradiated with single doses ranging from 1 to 6 Gy, and the clonogenic assay was adopted to evaluate cell survival after irradiation. The radiobiological results suggest that proton irradiation can cause significant lethal damages in both normal and cancerous cells. The obtained experimental data from biological models will serve for comparisons with Monte Carlo simulations and LEM II calculations.",
journal = "INFN-LNS Activity Report 2020",
title = "Radiosensitivity of uveal melanoma cells to photons and protons",
pages = "131-132",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13495"
}
Keta, O., Petković, V., Petringa, G., Cirrone, G.A.P., Cammarata, F., Minafra, L., Cuttone, G., Petrović, I. M.,& Ristić-Fira, A.. (2020). Radiosensitivity of uveal melanoma cells to photons and protons. in INFN-LNS Activity Report 2020, 131-132.
https://hdl.handle.net/21.15107/rcub_vinar_13495
Keta O, Petković V, Petringa G, Cirrone G, Cammarata F, Minafra L, Cuttone G, Petrović IM, Ristić-Fira A. Radiosensitivity of uveal melanoma cells to photons and protons. in INFN-LNS Activity Report 2020. 2020;:131-132.
https://hdl.handle.net/21.15107/rcub_vinar_13495 .
Keta, Otilija, Petković, Vladana, Petringa, G., Cirrone, G.A.P., Cammarata, F., Minafra, L., Cuttone, G., Petrović, Ivan M., Ristić-Fira, Aleksandra, "Radiosensitivity of uveal melanoma cells to photons and protons" in INFN-LNS Activity Report 2020 (2020):131-132,
https://hdl.handle.net/21.15107/rcub_vinar_13495 .
